Chien-Ting Lin

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Genetic polymorphisms of drug metabolizing enzymes, such as cytochromes P450 (CYPs), play major roles in the variations of drug responsiveness in human. The aim of this study is to identify the high prevalence (minor allele frequencies >1%) of the abnormal metabolite alleles of CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A5 in the Taiwanese population. The(More)
We study the dynamics of protein folding via statistical energy-landscape theory. In particular, we concentrate on the local-connectivity case with the folding progress described by the fraction of native conformations. We found that the first passage-time (FPT) distribution undergoes a dynamic transition at a temperature below which the FPT distribution(More)
Platelets are an ideal model for studying a rapid morphological change in response to various signal transduction systems. Morphological changes via the activation of integrin alphaIIbbeta3 in platelets have been investigated intensively. In contrast, activation via integrin alpha6beta1 is less well studied. Here, we provide the first biochemical evidence(More)
In this work, influences of oxygen effect on an Hf-based high-k gate dielectric were investigated. A post deposition annealing (PDA) including oxygen ion after high-k dielectric deposition was used to improve reliability of the Hf-based high-k/metal gate device. The basic electrical characteristics of devices were compared with and without the PDA process.(More)
The use of hybrid orientation technology (HOT) with direct silicon bond (DSB) wafers consisting of a (110) crystal orientation layer bonded to a bulk (100) handle wafer provides promising opportunities for easier migration of bulk CMOS designs to higher performance materials. In this work, the integration of shallow-trench-isolation (STI) after(More)
This paper describes a comprehensive study of the impact of tCESL (tensile Contact Etch Stop Liner) and cCESL (compressive Contact Etch Stop Liner) on tensile metal gate MuGFET with SOI and globally strained SOI (sSOI) substrates. We have demonstrated that tCESL and cCESL can be effectively used on MuGFETs to provide performance gain. Since tCESL and cCESL(More)