Chien-Kang Huang

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This paper proposes an effective term suggestion approach to interactive Web search. Conventional approaches to making term suggestions involve extracting co-occurring keyterms from highly ranked retrieved documents. Such approaches must deal with term extraction difficulties and interference from irrelevant documents, and, more importantly, have difficulty(More)
Peanut witches'-broom (PnWB) phytoplasma are obligate bacteria that cause leafy flower symptoms in Catharanthus roseus. The PnWB-mediated leafy flower transitions were studied to understand the mechanisms underlying the pathogen-host interaction; however, our understanding is limited because of the lack of information on the C. roseus genome. In this study,(More)
Protein-DNA interactions are essential for fundamental biological activities including DNA transcription, replication, packaging, repair and rearrangement. Proteins interacting with DNA can be classified into two categories of binding mechanisms - sequence-specific and non-specific binding. Protein-DNA specific binding provides a mechanism to recognize(More)
RNA-binding proteins (RBPs) play crucial roles in post-transcriptional control of RNA. RBPs are designed to efficiently recognize specific RNA sequences after it is derived from the DNA sequence. To satisfy diverse functional requirements, RNA binding proteins are composed of multiple blocks of RNA-binding domains (RBDs) presented in various structural(More)
This article presents the design of a sequence-based predictor named ProteDNA for identifying the sequence-specific binding residues in a transcription factor (TF). Concerning protein-DNA interactions, there are two types of binding mechanisms involved, namely sequence-specific binding and nonspecific binding. Sequence-specific bindings occur between(More)
Proteins are dynamic macromolecules which may undergo conformational transitions upon changes in environment. As it has been observed in laboratories that protein flexibility is correlated to essential biological functions, scientists have been designing various types of predictors for identifying structurally flexible regions in proteins. In this respect,(More)
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This paper proposes a new method EMPSC for the well-known PSC (Protein Structure Comparison) problem. The proposed method EMPSC is a protein structural alignment algorithm based on ellipsoidal model abstraction. We segment the protein 3D structure into two different kinds of structures, including Secondary Structure Elements recognized by DSSP and other(More)