Chien-Hui Hong

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BACKGROUND/AIMS Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in the TSC1 and TSC2 genes. Previous studies have estimated the prevalence of TSC to be 1:8,000 to 1:30,000. The numbers of patients and the populations accessed in these studies are relatively small. The aim of this study is to evaluate the prevalence of(More)
BACKGROUND Patients with tuberous sclerosis complex (TSC) are predisposed to developing ungual fibromas and other acral lesions. OBJECTIVE We sought to determine the numbers, types, and locations of acral skin lesions in TSC. METHODS We examined and photographed 76 adult women with TSC. RESULTS The age of the patients ranged from 20 to 69 years, with(More)
BACKGROUND Tuberous sclerosis complex (TSC) is associated with tumor development in the brain, retina, kidney, skin, heart, and lung. Seizures, intellectual disability, and characteristic skin lesions commonly manifest in early childhood, but some findings, notably renal angiomyolipomas and pulmonary lymphangioleiomyomatosis (LAM), emerge later, placing(More)
Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Atopic dermatitis (AD) is a common pruritic skin disease that greatly impairs quality of life (1). The pathophysiology of pruritus in AD is complex, but may involve several proinflammatory cytokines. One of these cytokines, interleukin-31 (IL-31), which is mainly expressed by Th2 cells,(More)
Arsenic remains an important environmental hazard that causes several human cancers. Arsenic-induced Bowen's disease (As-BD), a skin carcinoma in situ, is the most common arsenical cancer. While great strides have been made in our understanding of arsenic carcinogenesis, how host immunity contributes to this process remains unknown. Patients with As-BD have(More)
The human skin is an integral system that acts as a physical and immunological barrier to outside pathogens, toxicants, and harmful irradiations. Environmental ultraviolet rays (UV) from the sun might potentially play a more active role in regulating several important biological responses in the context of global warming. UV rays first encounter the(More)
Arsenic-induced Bowen's disease (As-BD), a cutaneous carcinoma in situ, is thought to arise from gene mutation and uncontrolled proliferation. However, how mitochondria regulate the arsenic-induced cell proliferation remains unclear. The aim of this study was to clarify whether arsenic interfered with mitochondrial biogenesis and function, leading to(More)
PURPOSE To determine if sclerotic bone lesions evident at body computed tomography (CT) are of value as a diagnostic criterion of tuberous sclerosis complex (TSC) and in the differentiation of TSC with lymphangioleiomyomatosis (LAM) from sporadic LAM. MATERIALS AND METHODS Informed consent was signed by all patients in this HIPAA-compliant study approved(More)
BACKGROUND Gingival fibromas and dental pitting are among the diagnostic criteria for tuberous sclerosis complex (TSC). OBJECTIVE Our goal was to document the oral findings in 58 adult patients with TSC. RESULTS Forty patients (69%) had oral fibromas, appearing mostly on the attached or interdental gingiva. Other oral mucosal sites with fibromas(More)
Atopic dermatitis is a chronic inflammatory skin disease. Multiple genetic and environmental factors are thought to be responsible for susceptibility to AD. In this study, we collected 2,478 DNA samples including 209 AD patients and 729 control subjects from Taiwanese population and 513 AD patients and 1027 control subject from Japanese population for(More)