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Gray matter volume in major depressive disorder: A meta-analysis of voxel-based morphometry studies
  • Chien-Han Lai
  • Medicine, Psychology
    Psychiatry Research: Neuroimaging
  • 30 January 2013
TLDR
This meta-analysis suggested GM deficits of the anterior cingulate cortex might be important in the etiology of MDD.
First episode drug-naïve major depressive disorder with panic disorder: Gray matter deficits in limbic and default network structures
TLDR
The results suggested that this group of patients has possible deficits of gray matter volumes over the default-mode network, fronto-cingulate and limbic structures, which might have started since the first episode.
Fronto-occipital fasciculus, corpus callosum and superior longitudinal fasciculus tract alterations of first-episode, medication-naïve and late-onset panic disorder patients.
TLDR
First-episode, medication-naïve and late-onset panic disorder patients had altered integrity in WM tracts of right inferior fronto-occipital fasculi, left body of corpus callosum and left superior longitudinal fasciculus when compared to controls.
Major Depressive Disorder: Gender Differences in Symptoms, Life Quality, and Sexual Function
  • Chien-Han Lai
  • Psychology, Medicine
    Journal of clinical psychopharmacology
  • 1 February 2011
TLDR
Patients with MDD showed a correlation between symptoms and functional impairment, and female patients might be more sexually impaired, more vegetative, more depressed, and experiencing more sadness and physical pain.
Frontal regional homogeneity increased and temporal regional homogeneity decreased after remission of first-episode drug-naïve major depressive disorder with panic disorder patients under duloxetine
OBJECTIVE We designed this study to investigate the changes of regional homogeneity (ReHo) after a 6-week duloxetine therapy in first-episode drug-naïve major depressive disorder with panic disorder
Fronto-temporo-insula gray matter alterations of first-episode, drug-naïve and very late-onset panic disorder patients.
TLDR
Fonto-temporo-insula gray matter deficits might represent the structural pathophysiology of first-episode, drug-naïve and very late-onset panic disorder.
A subtle grey-matter increase in first-episode, drug-naive major depressive disorder with panic disorder after 6 weeks' duloxetine therapy.
TLDR
It is suggested that short-term duloxetine therapy improved the clinical symptoms of patients with major depressive disorder combined with panic disorder and might be related to a modest increase of grey matter in state marker regions of the brain.
The alterations in regional homogeneity of parieto-cingulate and temporo-cerebellum regions of first-episode medication-naïve depression patients
TLDR
MDD patients had significant alterations in the ReHo of the parieto-cingulate and temporo-cerebellum regions with opposite trends, and these values were negatively correlated with the depression severity and with illness duration in the right anterior cingulate cortex.
The patterns of fractional amplitude of low-frequency fluctuations in depression patients: the dissociation between temporal regions and fronto-parietal regions.
TLDR
MDD patients had dissociable alterations in the fALFF values of the fronto-parietal and temporal regions, which might be unique for depression patients with later onset-age of young adult phase.
Gray Matter Deficits in Panic Disorder: A Pilot Study of Meta-Analysis
  • Chien-Han Lai
  • Psychology, Medicine
    Journal of clinical psychopharmacology
  • 1 June 2011
TLDR
Patients with PD possibly have decreased gray matter volumes in the striatolimbic areas, and more studies with whole-brain voxel-based morphometry in PD and first-episode drug-naive studies might elucidate structural deficits.
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