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This study uses stable isotope methodology to evaluate the validity of 6beta-hydroxylation clearance of endogenous cortisol as a new index for in vivo CYP3A phenotyping in humans. Important factors contradictory to the use of a conventional index of urinary ratio of 6beta-hydroxycortisol to cortisol (6beta-OHF/F) to evaluate in vivo CYP3A activity are also(More)
BACKGROUND Coronary artery disease (CAD) is a major problem worldwide. Atherosclerosis and thrombosis underlying CAD involve multiple cell types. New and useful diagnostic markers are required. MicroRNAs (miRNAs) are a class of noncoding RNAs that posttranscriptionally regulate the gene expressions involved in various cellular processes. Endothelial(More)
For pharmacists to enhance skill of pharmaceutical cares, it is necessary to learn many instructive clinical cases, which include drug-related incidences and checks of medication errors by pharmacists. However, these cases tend to be kept in each facility and there is no access to the cases for outside pharmacists. Therefore, we aimed to develop an(More)
A camphorquinone-derived chiral homoallylic amine was found to react with various aldehydes via imine formation and asymmetric 2-azonia-Cope rearrangement to give optically active homoallylic primary amines. A practical level of enantioselectivity with high functional group tolerance has been attained in this transformation.
The purpose of this study was to investigate the influence of sex and age on the selection of color, size, and form of anterior teeth for complete dentures. A sample representing one hundred eighty-five edentulous patients whose complete dentures were made with. Real Crown teeth (Shofu Inc.) was obtained. The results were as follows: 1) Lighter teeth were(More)
This study describes a high-performance liquid chromatographic (HPLC) method for the simultaneous determination of 6beta-hydroxycortisol (6beta-OHF) and cortisol in human urine using either methylprednisolone or beclomethasone as internal standard. Separation was achieved on a reversed-phase phenyl column by a gradient elution of 0.05 M KH(2)PO(4)-0.01 M(More)
  • Chieko Mori
  • Kokubyo Gakkai zasshi. The Journal of the…
  • 2002
The purpose of this study was to evaluate oral health promotion activities at the work site, for three years. The subjects were 486 workers (men, 340; women, 146) and the mean age was 27.0. We examined the oral health status of the subjects once a year for three years from 1997 to 1999. We also asked them to complete questionnaires on oral health symptoms(More)
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