Chieko Ishiguro

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BACKGROUND Antihypertensive and non-steroidal anti-inflammatory drugs (NSAIDs) are used to treat many common diseases. However, it has been suspected that interactions between these drugs exist. Here, we assessed the interactions between non-selective NSAIDs and several classes of antihypertensive drugs. METHODS The study design was a cohort study using(More)
Drug Safety Communications (DSCs), a major tool for risk communication used by the US Food and Drug Administration (FDA), are also designed to encourage spontaneous reporting. However, the effectiveness of this tool remains unclear. The objectives of this study were to evaluate changes in the frequency of spontaneous reporting before and after the release(More)
Drug agencies and pharmaceutical companies are responsible for continuously monitoring drug safety profiles to implement necessary safety measures. Retrospective analyses of safety-related regulatory actions (SRRAs) are known to be helpful as a tool for evaluating postmarketing safety in Western countries. However, few studies have examined the relationship(More)
The Escherichia coli MutT protein hydrolyzes 8-hydroxy-dGTP (8-OH-dGTP) in vitro, and mutT gene deficiencies cause increased spontaneous A:T-->C:G mutations. However, no direct evidence exists for enhanced mutagenicity of 8-OH-dGTP in mutT cells. In this study, 8-OH-dGTP was introduced into wild type and mutT E. coli cells, and mutations of a chromosomal(More)
INTRODUCTION Although hyperlipidemia is a well known adverse event of atypical antipsychotic (AAP) medication, there are few studies that have quantitatively compared the risks of various AAPs. OBJECTIVE Our aim was to comparatively evaluate the risk of hyperlipidemia associated with the use of AAPs approved in Japan through a consecutive epidemiological(More)
To evaluate the in vivo mutagenicities of damaged DNA precursors (deoxyribonucleoside 5'-triphosphates) produced by exposure to nitric oxide (NO) and ionizing radiation, five damaged deoxyribonucleotides (deoxyxanthosine triphosphate, deoxyoxanosine triphosphate, dITP, dUTP, and 8-hydroxy-dATP) were introduced into competent Escherichia coli cells. Their(More)
BACKGROUND Delirium is a common and serious clinical problem for hospitalized patients and is associated with an increased risk of morbidity and mortality and increased healthcare costs. OBJECTIVE The objective of this study was to investigate the preliminary usefulness of a novel delirium training program to improve nurses' self-confidence in caring for(More)
Oxidatively damaged DNA precursors (deoxyribonucleotides) are formed by reactive oxygen species. After the damaged DNA precursors are incorporated into DNA, they might be removed by DNA repair enzymes. In this study, to examine whether a nucleotide excision repair enzyme, Escherichia coli UvrABC, could suppress the mutations induced by oxidized(More)
BACKGROUND The evidence to date on the relationship between antipsychotic drugs and the risk of venous thromboembolism (VTE) is limited. PURPOSE Our aim was to examine the association between the use of typical and atypical antipsychotics and risk of VTE and to assess the effects of dose and duration of use. METHODS Among users of typical or atypical(More)