Chieh-Lin Wu

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BACKGROUND It is essential to subculture the cells once cultured cells reach confluence. For this, trypsin is frequently applied to dissociate adhesive cells from the substratum. However, due to the proteolytic activity of trypsin, cell surface proteins are often cleaved, which leads to dysregulation of the cell functions. METHODS In this study, a(More)
Renal cell carcinoma (RCC) is a malignancy with poor prognosis. WNT/β-catenin signaling dysregulation, especially β-catenin overactivation and WNT antagonist silencing, is associated with RCC carcinogenesis and progression. However, the role of WNT ligands in RCC has not yet been determined. We screened 19 WNT ligands from normal kidney and RCC cell lines(More)
BACKGROUND Angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphisms have been associated with acute coronary syndrome (ACS); however, several controversial results have also been found in different studied populations. This hospital-based, emergency room, case-control study in Taiwan retrospectively investigated 111 ACS patients, and(More)
Dysregulated β -catenin signaling is intricately involved in renal cell carcinoma (RCC) carcinogenesis and progression. Determining potential β -catenin signaling inhibitors would be helpful in ameliorating drug resistance in advanced or metastatic RCC. Screening for β -catenin signaling inhibitors involved in silico inquiry of the PubChem Bioactivity(More)
Moments is a wearable device designed for helping people suffering from early stage Alzheimer's disease (AD) be able to walk alone outdoors independently. Moments is featured by a voice control interface that allows users to follow pre-recorded instructions to travel along the routes preset by their care partners. We conducted user and expert research and(More)
Dysregulated í µí»½-catenin signaling is intricately involved in renal cell carcinoma (RCC) carcinogenesis and progression. Determining potential í µí»½-catenin signaling inhibitors would be helpful in ameliorating drug resistance in advanced or metastatic RCC. Screening for í µí»½-catenin signaling inhibitors involved in silico inquiry of the PubChem(More)
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