Chiara Rostello

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We sought to evaluate a new protocol designed to maintain long-term, nonrecovery, surgical anesthesia in Sprague-Dawley rats. In the first phase, two groups of rats were anesthetized with two different dose combinations of Domitor (medetomidine) and Zoletil 100 (tiletamine-zolazepam) to investigate their efficacy in induction of anesthesia. One combination(More)
INTRODUCTION The combined evaluation of physiology and behaviour allows a complete and more comprehensive pre-clinical assessment of central nervous system (CNS) function. An integrated video-telemetric electroencephalography (Video-tEEG) system, which allows the simultaneous and continuous recording of EEG and video images for long periods, was developed.(More)
Elena Moscardo, Chiara Rostello, Eric Rieux, and Reinko Roelofs 1 Safety Pharmacology Group, Dept. Safety Assessment, and Animal Model Investigator Support Group, Laboratory Animal Science, GlaxoSmithKline R&D Centre, Verona, Italy, elena.2.moscardo@gsk.com and chiara.b.rostello@gsk.com Eric Rieux, Data Science International, St. Paul, USA,(More)
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