Chiara Pighi

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Mantle cell lymphoma (MCL) is currently an incurable entity, and new therapeutic approaches are needed. We have applied a high-throughput phospho-proteomic technique to MCL cell lines to identify activated pathways and we have then validated our data in both cell lines and tumor tissues. PhosphoScan analysis was performed on MCL cell lines. Results were(More)
Activation-induced cytidine deaminase (AID) is a B-cell-specific enzyme that targets immunoglobulin genes to initiate class switch recombination and somatic hypermutation. In addition, through off-target activity, AID has a much broader effect on genomic instability by initiating oncogenic chromosomal translocations and mutations involved in the development(More)
In this paper we present VDJSeq-Solver, a methodology and tool to identify clonal lymphocyte populations from paired-end RNA Sequencing reads derived from the sequencing of mRNA neoplastic cells. The tool detects the main clone that characterises the tissue of interest by recognizing the most abundant V(D)J rearrangement among the existing ones in the(More)
Mantle cell lymphoma shows a peculiar immunogenetic profile, but the functional consequences of this fact are unknown. We have determined the precise sequences of rearranged heavy and light chain genes in several mantle cell lymphoma cell lines and investigated the presence of heavy and light chain stereotypy. These cell lines use IGHV and IGLV genes that(More)
Vladan Mijatovic1, Luciano Xumerle1, Alberto Ferrarini2, Ilaria Iacobucci3, Chiara Pighi4, Antonio Mori1, Chiara Zusi1, Paola Prandini1, Elisabetta Trabetti1, Massimo Delledonne1, Giovanni Martinelli3, Albert Zamò4, Pier F Pignatti1, Giovanni Malerba1 1Department of Life and Reproductions Sciences, University of Verona, Verona, Italy 2Department of(More)
Immunoglobulin heavy and light chains are assembled respectively from germline V, D, J and V, J segments within a process called V(D)J recombination involving the development of T and B lymphocytes. The discovery that abnormal antibodies are often related to a wide range of pathologies conducted during the last years to many studies inherent the(More)
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