Chiara Orlandi

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Hematopoiesis entails a series of hierarchically organized events that proceed throughout cell specification and terminates with cell differentiation. Commitment needs the transcription factors' effort, which, in concert with microRNAs, drives cell fate and responds to promiscuous patterns of gene expression by turning on lineage-specific genes and(More)
BACKGROUND MHC class II transactivator CIITA inhibits the function of HTLV-2 Tax-2 viral transactivator and, consequently, the replication of the virus in infected cells. Moreover overexpression of the nuclear factor NF-YB, that cooperates with CIITA for the expression of MHC class II genes, results also in inhibition of Tax-2 transactivation. The purpose(More)
Antibody-dependent cell-mediated cytotoxicity (ADCC) by non-neutralizing antibodies (nnAbs) specific to the HIV envelope (Env) glycoproteins present at the surface of virus sensitized or infected cells plays a role in the effective adaptive immune response to HIV. Here, we explore the molecular basis for the epitope at the disulfide loop region (DLR) of the(More)
CIITA, the MHC class II transactivator, inhibits the transcriptional function of HTLV-2 (Human T cell Lym-photropic Virus 2) Tax-2 viral transactivator and, consequently , the replication of the virus in human target cells. Here we demonstrate that CIITA and Tax-2 interact in vivo and we identified at least two independent regions, at the 1-252 N-term and(More)
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