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Many long-term prospective studies have reported on associations of cardiovascular diseases with circulating lipid markers and/or inflammatory markers. Studies have not, however, generally been designed to provide reliable estimates under different circumstances and to correct for within-person variability. The Emerging Risk Factors Collaboration has(More)
The epidemic dimensions of non-dialysis chronic kidney disease (CKD) and the associated elevated cardiovascular risk as well as the high costs of renal replacement therapy have made the identification of CKD patients and the quantification of CKD-related comorbidities a key priority in the strategies of public health agencies worldwide. Information on the(More)
PURPOSE The Italian national prevention plan 2005-2008 included 10-year cardiovascular risk (10-CR) assessment of the general population aged 35-69 years using the CUORE project risk score. General practitioners (GPs) were encouraged to collect data on risk factors and 10-CR and to contribute to the Cardiovascular Risk Observatory (CRO). The aim is to(More)
IMPORTANCE The prevalence of cardiometabolic multimorbidity is increasing. OBJECTIVE To estimate reductions in life expectancy associated with cardiometabolic multimorbidity. DESIGN, SETTING, AND PARTICIPANTS Age- and sex-adjusted mortality rates and hazard ratios (HRs) were calculated using individual participant data from the Emerging Risk Factors(More)
BACKGROUND Many publications report the prevalence of chronic kidney disease (CKD) in the general population. Comparisons across studies are hampered as CKD prevalence estimations are influenced by study population characteristics and laboratory methods. METHODS For this systematic review, two researchers independently searched PubMed, MEDLINE and EMBASE(More)
PURPOSE We studied the natural history of renal function following removal of different amounts of renal mass in a cohort of children with unilateral renal tumors. MATERIALS AND METHODS We compared kidney function and blood pressure before and after surgery in 26 patients with unilateral renal tumors treated with nephrectomy (group 1, 16 patients) or(More)
BACKGROUND Cardiovascular risk factor research has recently broadened its focus based on new data indicating the benefits of low risk, i.e. favorable levels of all major risk factors. The aims of this study were to assess further the relation of low risk to coronary heart disease risk, and implications for prevention. DESIGN We conducted a prospective(More)
BACKGROUND Social factors could offer useful information for planning prevention strategy for cardiovascular diseases. This analysis aims to explore the relationship between education, marital status and major cardiovascular risk factors and to evaluate the role of social status indicators in predicting cardiovascular events and deaths in several Italian(More)
Recently, the focus of research on cardiovascular risk factors has broadened because of new data demonstrating benefits of low risk (i.e., favorable) levels of all major modifiable risk factors. Most data on low risk relate to coronary heart disease, not stroke. This population-based, 12-sample, Italian study (Progetto CUORE, 1983-2002), with 10-year(More)
BACKGROUND The aim of this study was to build risk charts for the assessment of cardiovascular mortality of the CUORE project, an Italian longitudinal study, and to compare them with the systematic coronary risk evaluation (SCORE) project charts for low risk European countries. DESIGN Random population samples enrolled in the 1980s and 1990s in Italy were(More)