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BACKGROUND The FOLFOXIRI regimen produces a high rate of radiological and histopathological responses. Bevacizumab added to chemotherapy showed an improvement in pathological response and necrosis of colorectal liver metastases (CLMs). FOLFOXIRI plus bevacizumab produced promising early clinical results and is under investigation in several randomised(More)
Sir, We have read with great interest the recent paper by Portal et al (2015), who reported the results of a prospective multicentre cohort study evaluating the efficacy and safety of nab-paclitaxel plus gemcitabine after FOLFIRINOX failure in patients with metastatic pancreatic cancer (mPC). The authors collected the data of 110 patients from 12 French(More)
Recently, the development of the third-generation epidermal growth factor receptor-small molecule inhibitor (EGFR-TKI) rociletinib had failed. In this review, the wide-ranging aspects of the evolution of EGFR-TKIs were collected, with a special focus on rociletinib. The influence of different oncogenic mutations on EGFR activity was also discussed.(More)
BACKGROUND Few data are available comparing intragastric pH measured with the traditional catheter-based and the more recent wireless system (Bravo), and also comparing intraesophageal and intragastric pH during reflux events. Aims of our study were to elucidate these points. METHODS Eleven subjects with functional dyspepsia underwent placement of a Bravo(More)
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