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Cytotoxic T lymphocyte-associated molecule-4 polymorphism and relapse of Graves' hyperthyroidism after antithyroid withdrawal.
We studied the A/G single nucleotide polymorphism (SNP) at position 49 in exon 1 of the cytotoxic T lymphocyte-associated molecule-4 gene in 148 Chinese Graves' disease (GD) patients and 171… Expand
Expression of toll-like receptors and type 1 interferon specific protein MxA in biliary atresia
Viral infection and type I interferon have been implicated in the pathogenesis of biliary atresia (BA), but the expression of toll-like receptors (TLRs) that recognize viruses, as well as of type 1… Expand
Interleukin-10 gene therapy reverses thioacetamide-induced liver fibrosis in mice.
- Kung-sheng Hung, Tsung-hsing Lee, +5 authors Cheng-Huang Wang
- Biology, Medicine
- Biochemical and biophysical research…
- 14 October 2005
Hepatic fibrosis represents a process of healing and scarring in response to chronic liver injury. Interleukin-10 (IL-10) is a cytokine that downregulates the proinflammatory response and has a… Expand
Increased endostatin/collagen XVIII expression correlates with elevated VEGF level and poor prognosis in hepatocellular carcinoma
Liver is the primary source for collagen XVIII, the precursor of angiogenesis inhibitor, endostatin. However, the role of endostatin/collagen XVIII expression during liver carcinogenesis remains… Expand
Electroporative interleukin-10 gene transfer ameliorates carbon tetrachloride-induced murine liver fibrosis by MMP and TIMP modulation
AbstractAim:Liver fibrosis represents a process of healing and scarring in response to chronic liver injury. Effective therapies for liver fibrosis are lacking. Interleukin-10 (IL-10) is a cytokine… Expand
Nuclear factor‐κB signalling and transcriptional regulation in skeletal muscle atrophy
- R. Jackman, E. Cornwell, Chia-ling Wu, S. Kandarian
- Chemistry, Medicine
- Experimental physiology
- 1 January 2013
• What is the topic for this review? An up‐to‐date analysis on the role of nuclear factor‐κB signaling and transcriptional control in adult skeletal muscle atrophy. • What advances does it… Expand
Identification of transforming growth factors actively transcribed during the progress of liver fibrosis in biliary atresia.
BACKGROUND/PURPOSE Transforming growth factor-beta (TGF-beta) 1 and 2 and their receptors TbetaR-I, TbetaR-II, and TbetaR-III are powerful profibrogenic mediators in the body. Their expression has… Expand
The interleukin-4 expression in patients with severe sepsis.
PURPOSE Sepsis is a complicated syndrome in which proinflammatory and anti-inflammatory cytokines are expressed simultaneously. However, it remains unclear for the expression of interleukin (IL)-4… Expand
Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells
BackgroundToll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system. However, it remains unknown whether TLR3… Expand
Alpha-melanocyte-stimulating hormone gene therapy reverses carbon tetrachloride induced liver fibrosis in mice.
BACKGROUND Hepatic fibrosis represents a process of healing and scarring in response to chronic liver injury. Effective therapies are lacking. We have previously demonstrated that… Expand