Chia-Ying Yang

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MOTIVATION To fully understand how a protein kinase regulates biological processes, it is imperative to first identify its substrate(s) and interacting protein(s). However, of the 518 known human serine/threonine/tyrosine kinases, 35% of these have known substrates, while 14% of the kinases have identified substrate recognition motifs. In contrast, 85% of(More)
The bone remodeling process involved in orthodontic tooth movement consists of bone resorption on the compression side and bone formation on the tension side of the teeth. Osteoclasts play an important role in bone remodeling and are necessary for orthodontic tooth movement. Receptor activator of nuclear factor-κB ligand (RANKL) is essential for osteoclast(More)
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