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This paper presents a robust algorithm for exemplar-based image inpainting. We focus on the development of a generic priority function to provide robust performance. With user intervention, the algorithm is easy to be applied to any image contents with different characteristics. We conduct experiments on several kinds of still images and demonstrate the(More)
Increasing the in vivo residence times of protein therapeutics could decrease their dosing frequencies. We show that genetic fusion of an unstructured recombinant polypeptide of 864 amino acids, called XTEN, to a peptide or protein provides an apparently generic approach to extend plasma half-life. Allometric scaling suggests that a fusion of XTEN to the(More)
BACKGROUND Proprioception can be affected by many factors such as age, gender, injury, disease, exercise, and fatigue. To date, the mechanisms or pathways by which fatigue influences proprioception have not been elucidated. Generally, it is accepted that local muscular effects occurred during fatigue state may negatively affect proprioception. Research has(More)
OBJECTIVE To describe our experiences with the diagnosis and endoscopic treatment of cesarean scar pregnancy. DESIGN Prospective clinical study. SETTING Tertiary care university hospital. PATIENT(S) Eleven women treated in our division between 1999 and 2004 who had been diagnosed with cesarean scar pregnancy. INTERVENTION(S) Transvaginal ultrasound(More)
OBJECTIVES Glucagon-like peptide 2 (GLP2) is an intestinal growth factor that has been shown to stimulate intestinal growth and reduce disease severity in preclinical models of short bowel syndrome and inflammatory bowel disease. Teduglutide, a recombinant human GLP2 variant (GLP2-2G), has increased half-life and stability as compared to the native GLP2(More)
XTENs are unstructured, nonrepetitive protein polymers designed to prolong the in vivo half-life of pharmaceuticals by introducing a bulking effect similar to that of poly(ethylene glycol). While XTEN can be expressed as a recombinant fusion protein with bioactive proteins and peptides, therapeutic molecules of interest can also be chemically conjugated to(More)
XTEN, unstructured biodegradable proteins, have been used to extend the in vivo half-life of genetically fused therapeutic proteins and peptides. To expand the applications of XTEN technology to half-life extension of other classes of molecules, XTEN protein polymers and methods for chemical XTENylation were developed. Two XTEN precursors were engineered to(More)
OBJECTIVE While the majority of current diabetes treatments focus on reducing blood glucose levels, hypoglycemia represents a significant risk associated with insulin treatment. Glucagon plays a major regulatory role in controlling hypoglycemia in vivo, but its short half-life and hyperglycemic effects prevent its therapeutic use for non-acute applications.(More)
AIM To examine the effect of regular ongoing exercise lifestyle on mental and physical health in a group of independent community-dwelling Taiwanese older adults over a 2-year period. METHODS 197 older adults (mean age 72.5 years; 106 men and 91 women) who were independent in walking, instrumental and basic activities of daily living completed the(More)
The Internet of Things (IoT) opens opportunities for wearable devices, home appliances, and software to share and communicate information on the Internet. Given that the shared data contains a large amount of private information, preserving information security on the shared data is an important issue that cannot be neglected. In this paper, we begin with(More)