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The Malicious Email Tracking (MET) system, reported in a prior publication, is a behavior-based security system for email services. The Email Mining Toolkit (EMT) presented in this paper is an offline email archive data mining analysis system that is designed to compute models of malicious email behavior for deployment in an online MET system. EMT includes(More)
The Email Mining Toolkit (EMT) is a data mining system that computes <i>behavior profiles or models</i> of user email accounts. These models may be used for a multitude of tasks including forensic analyses and detection tasks of value to law enforcement and intelligence agencies, as well for as other typical tasks such as virus and spam detection. To(More)
This paper describes the forensic and intelligence analysis capabilities of the Email Mining Toolkit (EMT) under development at the Columbia Intrusion Detection (IDS) Lab. EMT provides the means of loading, parsing and analyzing email logs, including content, in a wide range of formats. Many tools and techniques have been available from the fields of(More)
The Email Mining Toolkit (EMT) is a data mining system that computes behavior profiles or models of user email accounts. These models may be used for a variety of forensic analyses and detection tasks. In this paper we focus on the application of these models to detect the early onset of a viral propagation without "contentbased" (or signature-based)(More)
Protein phosphorylation regulated by plant hormone is involved in the coordination of fundamental plant development. Brassinosteroids (BRs), a group of phytohormones, regulated phosphorylation dynamics remains to be delineated in plants. In this study, we performed a mass spectrometry (MS)-based phosphoproteomics to conduct a global and dynamic(More)
ATP synthase is present on the plasma membrane of several types of cancer cells. Citreoviridin, an ATP synthase inhibitor, selectively suppresses the proliferation and growth of lung cancer without affecting normal cells. However, the global effects of targeting ectopic ATP synthase in vivo have not been well defined. In this study, we performed(More)
Citreoviridin, one of toxic mycotoxins derived from fungal species, can suppress lung cancer cell growth by inhibiting the activity of ectopic ATP synthase, but has limited effect on normal cells. However, the mechanism of citreoviridin triggering dynamic molecular responses in cancer cells remains unclear. Here, we performed temporal phosphoproteomics to(More)
MicroRNAs (miRNAs) are noncoding RNAs that control gene expression either by degradation of mRNAs or inhibition of protein translation. miR-148a has been reported to have the impacts on tumor progression. Here, a quantitative proteomics combined with stable isotope labeling was applied to identify the global profile of miR-148a-regulated downstream(More)
Rhodopseudomonas palustris (R. palustris) is a purple nonsulfur anoxygenic phototrophic bacterium with metabolic versatility and is able to grow under photoheterotrophic and chemoheterotrophic states. It has uses in carbon management, carbon recycling, hydrogen generation, and lipid production; therefore, it has the potential for bioenergy production and(More)