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The Malicious Email Tracking (MET) system, reported in a prior publication, is a behavior-based security system for email services. The Email Mining Toolkit (EMT) presented in this paper is an offline email archive data mining analysis system that is designed to compute models of malicious email behavior for deployment in an online MET system. EMT includes(More)
Protein phosphorylation regulated by plant hormone is involved in the coordination of fundamental plant development. Brassinosteroids (BRs), a group of phytohormones, regulated phosphorylation dynamics remains to be delineated in plants. In this study, we performed a mass spectrometry (MS)-based phosphoproteomics to conduct a global and dynamic(More)
ATP synthase is present on the plasma membrane of several types of cancer cells. Citreoviridin, an ATP synthase inhibitor, selectively suppresses the proliferation and growth of lung cancer without affecting normal cells. However, the global effects of targeting ectopic ATP synthase in vivo have not been well defined. In this study, we performed(More)
The Email Mining Toolkit (EMT) is a data mining system that computes <i>behavior profiles or models</i> of user email accounts. These models may be used for a multitude of tasks including forensic analyses and detection tasks of value to law enforcement and intelligence agencies, as well for as other typical tasks such as virus and spam detection. To(More)
Citreoviridin, one of toxic mycotoxins derived from fungal species, can suppress lung cancer cell growth by inhibiting the activity of ectopic ATP synthase, but has limited effect on normal cells. However, the mechanism of citreoviridin triggering dynamic molecular responses in cancer cells remains unclear. Here, we performed temporal phosphoproteomics to(More)
We introduce the Email Mining Toolkit (EMT), a system that implements behavior-based methods to improve security of email systems. Behavior models of email flows and email account usage may be used for a variety of detection tasks. Behavior-based models are quite different from "content-based" models in common use today, such as virus scanners. We evaluate(More)
Rhodopseudomonas palustris (R. palustris) is a purple nonsulfur anoxygenic phototrophic bacterium with metabolic versatility and is able to grow under photoheterotrophic and chemoheterotrophic states. It has uses in carbon management, carbon recycling, hydrogen generation, and lipid production; therefore, it has the potential for bioenergy production and(More)
O-GlcNAcylation is a nutrient-responsive glycosylation that plays a pivotal role in transcriptional regulation. Human RNA polymerase II (Pol II) is extensively modified by O-linked N-acetylglucosamine (O-GlcNAc) on its unique C-terminal domain (CTD), which consists of 52 heptad repeats. One approach to understanding the function of glycosylated Pol II is to(More)