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BACKGROUND AND OBJECTIVES Minocycline is a second-generation tetracycline with multiple biological effects, including inhibition of microglial activation. Recently, microglial activation has been implicated in the development of nerve injury-induced neuropathic pain. In this study, the authors examined the effects of continuous intrathecal minocycline on(More)
BACKGROUND AND OBJECTIVES Ganglion impar block is an uncommon procedure that has been performed traditional with fluoroscopy. One approach is the trans-sacrococcygeal approach. Sometimes this can be difficult because the sacrococcygeal joint (SCJ) cannot be readily seen on anteroposterior (AP) and lateral fluoroscopy. This technical report describes the(More)
T-type Ca2+ channels have been implicated in the induction of long-term potentiation, a synaptic plasticity involved in the central sensitization that contributes to the generation of inflammatory pain, in spinal sensory neurons. In this study, we examined the effects of intrathecal T-type Ca2+ channel blockers, mibefradil, ethosuximide and NiCl2, in the(More)
Platinum sols have been prepared by citrate reduction in the temperature range of 343-363 K. The Pt state in the solution was examined by EXAFS (extended X-ray absorption fine-structure spectroscopy). It did not show any PtPt bonding, a characteristic for reduced Pt sols. EXAFS model fitting further proved the presence of PtO with 4 oxygen neighbors, which(More)
Platinum nanoparticles of 2-3 nm average size and ca. +/-2 nm distribution can be successfully prepared by methanol reduction while using sodium citrate as the stabilizer. Sol formation was investigated by UV-visible spectroscopy and EXAFS (extended X-ray absorption fine structure spectroscopy). The formation of Pt nanoparticles was confirmed by the(More)
Pulmonary embolism (PE) is a rare but life-threatening condition, which needs emergent treatment in children. Though anticoagulation is the standard treatment for PE, recent studies revealed intrapulmonary thrombolytic therapy may produce more rapid clot lysis and less systemic complications in adult patients. We reported a 10-year-old girl who had diffused(More)
A 0D discrete molecule [Co(3,5-pdc)(H2O)5].2H2O (1) was obtained in quantitative yield from the reaction of CoCl2.6H2O and pyridine-3,5-dicarboxylate (3,5-pdc) in pure water solvent at ambient temperature. While a 1D zigzag chain species, [{Co(3,5-pdc)(H2O)4}.H2O]n (2), was produced in a water-rich environment, a 2D layer compound, [Co(3,5-pdc)(H2O)2]n (3),(More)
BACKGROUND Mirtazapine is a new antidepressant that blocks 5-HT2 and 5-HT3 receptors. With this receptor profile, it is possible that mirtazapine could provide both anxiolysis and efficacy for postoperative nausea and vomiting (PONV). We therefore tested the hypothesis that premedication with mirtazapine can reduce preoperative anxiety and PONV. METHODS(More)
BACKGROUND AND OBJECTIVE Gabapentin, an anticonvulsant with analgesic effect, has been reported to be an activator of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. In this study, we tested the effect of intrathecal ZD7288, an HCN channel inhibitor, and its interaction with intrathecal gabapentin in the rat formalin test. METHODS Male(More)