Chia-Sheng Chuang

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BACKGROUND Hypoxia-inducible factors (HIFs) are transcription factors that play a crucial role in response to hypoxic stress in living organisms. The HIF pathway is activated by changes in cellular oxygen levels and has significant impacts on the regulation of gene expression patterns in cancer cells. Identifying functional conservation across species and(More)
Simple Sequence Repeats (SSRs), also known as microsatellites, regulate gene functions. SSR mutations in a disease gene may cause various genetic disorders. To identify putative functional SSRs, a web-based system, Gene Ontology SSR Hierarchy (GOSH), was developed to facilitate discovery of significant associations between SSRs and Gene Ontology (GO) terms.(More)
Hypoxia-inducible factors (HIFs) are transcription factors that play a crucial role in adaptive processes to a hypoxic cellular environment for most of organisms. The activation of HIF pathway has significant impacts on gene expression patterns in cancer research and it is important to analyze functional conservation and possible gene replacement within the(More)
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