Chia-Min Chen

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Generally, a two-stage design is employed in Phase II clinical trials to avoid giving patients an ineffective drug. If the number of patients with significant improvement, which is a binomial response, is greater than a pre-specified value at the first stage, then another binomial response at the second stage is also observed. This paper considers interval(More)
The nucleocapsid (N) phosphoprotein of the severe acute respiratory syndrome coronavirus (SARS-CoV) packages the viral genome into a helical ribonucleocapsid and plays a fundamental role during viral self-assembly. The N protein consists of two structural domains interspersed between intrinsically disordered regions and dimerizes through the C-terminal(More)
Recently, the proliferation of smartphones and the extensive coverage of wireless networks have enabled numerous mobile users to access Web resources with smartphones. Mobile mashup applications are very attractive to smartphone users due to specialized services and user-friendly GUIs. However, to offer new services through the integration of Web resources(More)
The Neer I (polyethylene glenoid), Neer II (plastic glenoid surface with metal backing), Cofield, and Gristina monospherical total shoulder prostheses were tested for joint subluxation resistance and glenoid component fixation strength. Synthetic glenoid models with consistent structural properties and standard under-cutting geometry were used for glenoid(More)
Increased incidence of erectile dysfunction (ED) has been reported among patients with sleep apnea (SA). However, this association has not been confirmed in a large-scale study. We therefore performed a population-based cohort study using Taiwan National Health Insurance (NHI) database to investigate the association of SA and ED. From the database of one(More)
This paper presents a high-speed, low-glitch, and low-power design for a 10-bit binary-weighted current-steering digital-to-analog converter (DAC). Instead of using large input buffers to drive a lot of current switches and re-timing latches, the proposed design uses variable-delay buffers with a compact layout to compensate for the delay difference among(More)