Chia-Lung Hsieh

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We demonstrate focusing coherent light on a nanoparticle through turbid media based on digital optical phase conjugation of second harmonic generation (SHG) field from the nanoparticle. A SHG active nanoparticle inside a turbid medium was excited at the fundamental frequency and emitted SHG field as a point source. The SHG emission was scattered by the(More)
We demonstrate imaging through a turbid layer by using digital phase conjugation of the second harmonic field radiated from a beacon nanoparticle. We show that the phase-conjugated focus can be displaced from its initial position by illuminating the same region of the turbid layer with an angular offset. An image is obtained by scanning the phase-conjugated(More)
Luminescent markers play a key role in imaging techniques for life science since they provide a contrast mechanism between signal and background. We describe a new type of marker using second harmonic generation (SHG) from noncentrosymmetric BaTiO 3 nanocrystals. These nanoparticles are attractive due to their stable, non-saturating and coherent signal with(More)
We demonstrate that second-harmonic radiation imaging probes are efficient biomarkers for imaging in living tissue. We show that 100 nm and 300 nm BaTiO(3) nanoparticles used as contrast markers could be detected through 50 μm and 120 μm of mouse tail tissue in vitro or in vivo. Experimental results and Monte-Carlo simulations are in good agreement.
All Rights Reserved iii To my wife, Lun iv v Acknowledgements First, I would like to express my sincere gratitude to my advisor, Professor Demetri Psaltis, for his support and guidance throughout my graduate studies at Caltech. I'll be forever indebted to him for offering me the opportunity to pursue my PhD degree at the same school as my wife, not to(More)
Free-standing lithium niobate nanowires ͑LiNbO 3 ͒ are synthesized by the hydrothermal route. The polarization response of the second harmonic generation ͑SHG͒ signal is measured in a single nanowire and used to identify the crystal orientation by matching with bulk LiNbO 3 nonlinear optical susceptibility. The electrical manipulation of a LiNbO 3 nanowire(More)
Lipid rafts are membrane nanodomains that facilitate important cell functions. Despite recent advances in identifying the biological significance of rafts, nature and regulation mechanism of rafts are largely unknown due to the difficulty of resolving dynamic molecular interaction of rafts at the nanoscale. Here, we investigate organization and(More)