Chia-Ling Wu

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BACKGROUND AND PURPOSE Memory impairment can be progressive in neurodegenerative diseases, and physiological ageing or brain injury, mitochondrial dysfunction and oxidative stress are critical components of these issues. An early clinical study has demonstrated cognitive improvement during erythropoietin treatment in patients with chronic renal failure. As(More)
Skeletal muscle atrophy is a debilitating condition associated with weakness, fatigue, and reduced functional capacity. Nuclear factor-kappaB (NF-κB) transcription factors play a critical role in atrophy. Knockout of genes encoding p50 or the NF-κB co-transactivator, Bcl-3, abolish disuse atrophy and thus they are NF-κB factors required for disuse atrophy.(More)
The focus of this paper is to devise a service-oriented architecture for multi-agents system (called SAM), to reach a wide adoption and routine use of agents, web services, and semantic web technologies. In order to better integrate agents, web applications and information sources in an open and distributed environment such as the Internet, a service(More)
Recently, aspect-oriented approaches have resulted in a tremendous impact on the processing of broadly scoped properties during the development of software systems. However, the weaving mechanism of these crosscutting concerns cannot be easily represented with the extant uniÞed modeling language (UML) notation at the early stage of software development life(More)
BACKGROUND Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system. However, it remains unknown whether TLR3 may serve as a therapeutic target in human neuroblastoma (NB). METHODS TLR3 expression in human NB samples was examined by immunohistochemical analysis.(More)
Context: Agents are considered as one of the fundamental technologies underlying open and dynamic systems that are largely enabled by the semantic web and web services. Recently, there is a trend to introduce the notion of autonomy empowered by agents into web services. However, it has been argued that the characteristics of autonomy will make agents become(More)
Existing data suggest that NF-kappaB signaling is a key regulator of cancer-induced skeletal muscle wasting. However, identification of the components of this signaling pathway and of the NF-kB transcription factors that regulate wasting is far from complete. In muscles of C26 tumor bearing mice, overexpression of dominant negative (d.n.) IKKb blocked(More)
Although new analogues of immunomodulatory drugs (IMiDs) are being developed for MM, the molecular mechanism of these drugs remains unclear. In the current study, we used MM cell lines as a model to investigate the molecular mechanism of thalidomide and to compare its potency with IMiDs such as pomalidomide. We determined that thalidomide did not inhibit(More)
To determine the predominant staphylococcal cassette chromosome (SCC) mec element in methicillin-resistant Staphylococcus aureus, we typed 190 isolates from a hospital in Taiwan. We found a shift from type IV to type III SCCmec element during 1992-2003, perhaps caused by selective pressure from indiscriminate use of antimicrobial drugs.
NF-kappaB transcriptional activation is required for skeletal muscle disuse atrophy. We are continuing to study how the activation of NF-kB regulates the genes that encode the protein products that cause atrophy. Using ChIP-sequencing we found that Bcl-3, an NF-kB transcriptional activator required for atrophy, binds to the promoters of a number of genes(More)