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Influenza A (H(1)N(1)) Antiviral and Cytotoxic Agents from Ferula assa-foetida.
TLDR
Two new sesquiterpene coumarins were isolated from a CHCl(3)-soluble extract of Ferula assa-foetida through bioassay-guided fractionation and showed greater potency against influenza A virus than amantadine and exhibited the best potency against HepG2, Hep3B, and MCF-7 cancer cell lines.
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Antiviral Action of Tryptanthrin Isolated from Strobilanthes cusia Leaf against Human Coronavirus NL63
TLDR
Investigation of the anti-Human coronavirus NL63 activity of the methanol extract of S. cusia leaf found that tryptanthrin possesses antiviral potential against HCoV-NL63 infection.
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Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis.
Two new phenanthrenequinones, calanquinones B and C (2 and 3) and four new 9,10-dihydrophenanthrenes, calanhydroquinones A-C (4-6) and calanphenanthrene A (7), along with five known compounds (1 and…
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Anti-inflammatory and cytotoxic neoflavonoids and benzofurans from Pterocarpus santalinus.
Five new benzofurans, pterolinuses A-E (1-5), six new neoflavonoids, pterolinuses F-J (8-13), and five known compounds (6, 7, 14-16) were isolated from an extract of Pterocarpus santalinus heartwood.…
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Indiosides G-K: steroidal glycosides with cytotoxic and anti-inflammatory activities from Solanum violaceum.
TLDR
Five new steroidal glycosides (1-5) and nine known compounds were isolated from Solanum violaceum and structure-activity relationship correlations of these compounds with respect to cytotoxic and anti-inflammatory effects are discussed.
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Ixorapeptide I and ixorapeptide II, bioactive peptides isolated from Ixora coccinea.
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Lignan and flavonoid phytoestrogens from the seeds of Cuscuta chinensis.
TLDR
In a search for natural phytoestrogens, 130 traditional Chinese medicinal extracts related to gynecological disorders were investigated by the Arabidopsis pER8:GUS reporter assay system, which showed estrogenic activity and affored three new lignans, cuscutaresinols A−C (1−3), and 16 known compounds.
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Anti-inflammatory Cerebrosides from Cultivated Cordyceps militaris.
TLDR
The isolation of cerebrosides with anti-inflammatory activity from this TCM inhibited the accumulation of pro-inflammatory iNOS protein and reduced the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophages.
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First total synthesis of antrocamphin A and its analogs as anti-inflammatory and anti-platelet aggregation agents.
TLDR
This study is the first total synthesis of antrocamphin A and its analogs and their inhibition ability on NO release, superoxide anion generation, elastase release and platelet aggregation are reported herein.
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(-)-Xanthienopyran, a new inhibitor of superoxide anion generation by activated neutrophils, and further constituents of the seeds of Xanthium strumarium.
TLDR
Two new compounds, xanthialdehyde and (-)-xanthienopyran, as well as 26 known compounds were isolated from dried seeds of XANTHIUM STRUMARIUM (Asteraceae) and exhibited significant selective inhibition of superoxide anion generation by human neutrophils induced by formyl-L-methionyl- L-leucyl- L -phenylalanine.
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