Chia-Jen Wang

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Mesenchymal stromal cells (MSCs) are multilineage progenitors with immunomodulatory properties, including expansion of immunomodulatory leukocytes such as regulatory T lymphocytes (Tregs) and tolerogenic dendritic cells. We report that human MSCs can expand CD14(-)CD11b(+)CD33(+) human myeloid-derived suppressor cells (MDSCs). MSC-expanded MDSCs suppress(More)
RATIONALE Despite advances in treatment and prognosis of non-small cell lung cancer (NSCLC), patient outcomes are still unsatisfactory. OBJECTIVES To reduce the morbidity and mortality of patients with NSCLC, a more comprehensive understanding of mechanisms involved in cancer progression is urgently needed. METHODS By comparison of gene expression(More)
Content-based image retrieval (CBIR) work includes feature selection, object representation, and matching. If a shape is used as feature, edge detection might be the first step to extract that feature. Invariance to translation, rotation, and scale is required by a good shape representation. Sustaining deformation contour matching is an important issue at(More)
Angiogenesis, the process of new blood vessel formation, is important in wound healing, inflammation, tumorigenesis and metastases. During this process, it is a critical step of the loosening of cellular interactions between endothelial cells, which are dependent on the architecture of adherens junction constructed by homophilic interactions of cell surface(More)
OBJECTIVE Coinhibitory signals mediated via programmed death 1 (PD-1) receptor play a critical role in downregulating immune responses and in maintaining peripheral tolerance. Programmed death 1 ligand 1 (PD-L1), the interacting ligand for PD-1, widely expressed in many cell types, acts as a tissue-specific negative regulator of pathogenic T-cell responses.(More)
Interactions between maternal natural killer lymphocytes (NKs) and fetal tissues are important in mediating maternal-fetal tolerance. We therefore investigated the interactions of NKs to placenta-derived multipotent cells (PDMCs) isolated from the term human placenta. PDMCs have similar cell surface marker expression as bone marrow mesenchymal stem cells(More)
This paper presents a digital watermarking technique based on Support Vector Machines (SVMs). Use the nice characteristic of the SVM, which can result an optimal hyperplane for the given training samples, the imperceptibility and robustness requirements of watermarks are fulfilled and optimized. In the proposed scheme, to improve imperceptibility, the(More)
In this paper we present a scene-based video watermarking scheme using support vector machines (SVMs). In a given scene, the algorithm uses the first h′ frames to train an embedding SVM, and uses this SVM to watermark the rest of frames. In the extracting phrase, the detector uses center h frames of the first h′ frames to train an extracting SVM. The final(More)