Chia-Hsiung Cheng

Chang-Jen Huang8
Wan-Yu Hsu8
8Chang-Jen Huang
8Wan-Yu Hsu
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This study aimed to characterize the cortical deficits in processing auditory inputs in patients with Alzheimer's disease (AD). The magnetic counterparts of P50 (M50) and mismatch negativity (MMNm) during a passive oddball paradigm were analyzed with equivalent current dipole modeling. The results showed larger cortical activation of standard-evoked M50 in(More)
BACKGROUND AND PURPOSE The purpose of this study was to perform a meta-analysis of studies that investigated the effects of repetitive transcranial magnetic stimulation (rTMS) on upper limb motor function in patients with stroke. METHODS We searched for randomized controlled trials published between January 1990 and October 2011 in PubMed, Medline,(More)
BACKGROUND Cancer progression is closely linked to the epithelial-mesenchymal transition (EMT) process. Studies have shown that there is increased expression of tissue tranglutaminase (TG2) in advanced invasive cancer cells. TG2 catalyzes the covalent cross-linking of proteins, exhibits G protein activity, and has been implicated in the modulation of cell(More)
Primary somatosensory (SI) cortical inhibition to repetitive stimuli tends to decline with increasing age. However, aging effects on the inhibition mechanism of secondary somatosensory cortex (SII) remain elusive. We aimed to study the aging-related changes of cortical inhibition in the human somatosensory system. Neuromagnetic responses to paired-pulse(More)
Mismatch negativity (MMN) is a promising window on how the functional integrity of auditory sensory memory and change discrimination is modulated by age and relevant clinical conditions. However, the effects of aging on MMN have remained somewhat elusive, particularly at short interstimulus intervals (ISIs). We performed a meta-analysis of peer-reviewed MMN(More)
The ability to discriminate speech sounds is crucial for higher language functions in humans. However, it remains unclear whether physiological aging affects the functional integrity of pre-attentive phonological discrimination. The neuromagnetic cortical responses during automatic change detection of speech sounds (/ba/versus/da/) were recorded in 24 young(More)
Although aging-related alterations in the auditory sensory memory and involuntary change discrimination have been widely studied, it remains controversial whether the mismatch negativity (MMN) or its magnetic counterpart (MMNm) is modulated by physiological aging. This study aimed to examine the effects of aging on mismatch activity to pitch deviants by(More)
Sensory gating (SG), referring to an attenuated neural response to the second identical stimulus, is considered as preattentive processing in the central nervous system to filter redundant sensory inputs. Insufficient somatosensory SG has been found in the aged adults, particularly in the secondary somatosensory cortex (SII). However, it remains unclear(More)
Metastasis is a major cause of mortality in cancer patients. Invadopodia are considered to be crucial structures that allow cancer cells to penetrate across the extracellular matrix (ECM) by using matrix metalloproteinases (MMPs). Previously, we isolated a highly invasive A431-III subline from parental A431 cells by Boyden chamber assay. The A431-III cells(More)
PURPOSE To evaluate the antiepileptic efficacy of low frequency repetitive transcranial magnetic stimulation (rTMS) in medically intractable epilepsy. METHODS A comprehensive literature search was performed on articles published from 1990 to 2010 in Medline, Pubmed, CINAHL, and Cochrane using the following keywords: epilepsy, seizure, transcranial(More)