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Recent studies have indicated that high-density lipoproteins (HDLs) and their major structural protein, apolipoprotein A1 (apoA1), recovered from human atheroma are dysfunctional and are extensively oxidized by myeloperoxidase (MPO). In vitro oxidation of either apoA1 or HDL particles by MPO impairs their cholesterol acceptor function. Here, using phage(More)
Obesity is linked to type 2 diabetes (T2D) and cardiovascular diseases; however, the underlying molecular mechanisms remain unclear. We aimed to identify obesity-associated molecular features that may contribute to obesity-related diseases. Using circulating monocytes from 1,264 Multi-Ethnic Study of Atherosclerosis (MESA) participants, we quantified the(More)
Table grape consumption reduces adiposity and markers of hepatic lipogenesis and alters gut microbiota in butter fat-fed mice. serotonin exposure initiates arteriolar inward remodeling processes in vivo that involve transglutaminase activation and actin cytoskeleton reorganization." American Journal of Physiology-Heart and Circulatory Physiology (2015):(More)
"Myeloid cell-specific ABCA1 deletion does not worsen insulin resistance in HF dietinduced or genetically obese mouse models" (2013). Nutrition and Health Sciences-Faculty Publications. Paper 47. Abstract Obesity-associated low-grade chronic inflammation plays an important role in the development of insulin resistance. The membrane lipid transporter(More)
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