Chia-Chang Wang

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The packaging of DNA into chromatin regulates transcription from initiation through 3' end processing. One aspect of transcription in which chromatin plays a poorly understood role is the co-transcriptional splicing of pre-mRNA. Here we provide evidence that H2B monoubiquitylation (H2BK123ub1) marks introns in Saccharomyces cerevisiae. A genome-wide map of(More)
Biochemical pathways are gradually becoming recognized as central to complex human diseases and recently genetic/transcriptional interactions have been shown to be able to predict partial pathways. With the abundant information made available by microarray gene expression data (MGED), nonlinear modeling of these interactions is now feasible. Two of the(More)
In the past decades, a significant number of studies on the prediction of protein 3D tertiary structures have been extensively made. However, the folding rules, the core issue of protein structure prediction, still stay unsolved. Given a target protein with its primary amino acid sequence, the protein backbone structure prediction (PSP) problem is to(More)
MOTIVATION Most prokaryotic genomes are circular with a single chromosome (called circular genomes), which consist of bacteria and archaea. Orthologous genes (abbreviated as orthologs) are genes directly evolved from an ancestor gene, and can be traced through different species in evolution. Shared orthologs between bacterial genomes have been used to(More)
An S-shape model and an optimization algorithm (GASA) are developed to infer genetic interactions and transcriptional regulation of a few genes simultaneously using microarray gene expression data (MGED). GASA consists of a genetic algorithm and a simulated annealing (SA) algorithm, which is enhanced by a steepest gradient descent algorithm to avoid being(More)
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