Chia-Chang Wang

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BACKGROUND The packaging of DNA into chromatin regulates transcription from initiation through 3' end processing. One aspect of transcription in which chromatin plays a poorly understood role is the co-transcriptional splicing of pre-mRNA. RESULTS Here we provide evidence that H2B monoubiquitylation (H2BK123ub1) marks introns in Saccharomyces cerevisiae.(More)
BACKGROUND Biochemical pathways are gradually becoming recognized as central to complex human diseases and recently genetic/transcriptional interactions have been shown to be able to predict partial pathways. With the abundant information made available by microarray gene expression data (MGED), nonlinear modeling of these interactions is now feasible. Two(More)
MOTIVATION Most prokaryotic genomes are circular with a single chromosome (called circular genomes), which consist of bacteria and archaea. Orthologous genes (abbreviated as orthologs) are genes directly evolved from an ancestor gene, and can be traced through different species in evolution. Shared orthologs between bacterial genomes have been used to(More)
In the past decades, a significant number of studies on the prediction of protein 3D tertiary structures have been extensively made. However, the folding rules, the core issue of protein structure prediction, still stay unsolved. Given a target protein with its primary amino acid sequence, the protein backbone structure prediction (PSP) problem is to(More)
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