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Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis
The results indicate that BID is a mediator of mitochondrial damage induced by Casp8, and coexpression of BclxL inhibits all the apoptotic changes induced by tBID. Expand
Caspase-8 Is Required for Cell Death Induced by Expanded Polyglutamine Repeats
It is shown that caspase-8 is required for the death of primary rat neurons induced by an expanded polyglutamine repeat (Q79), and Western blot analysis revealed the presence of activated caspases in the insoluble fraction of affected brain regions from Huntington's disease patients but not in those from neurologically unremarkable controls, suggesting the relocation and activation of casp enzyme during the pathogenesis of HD. Expand
Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Transcriptional Activator Rta Is an Oligomeric DNA-Binding Protein That Interacts with Tandem Arrays of Phased A/T-Trinucleotide Motifs
The purification and characterizations of HHV-8 Rta support a model of Rta transactivation wherein the subunits of the Rta oligomer make multiple contacts with a tandem array of phased A/T triplets in the configuration of (A/T)3(G/C)7 repeats. Expand
Human angiogenin is rapidly translocated to the nucleus of human umbilical vein endothelial cells and binds to DNA
Results suggest that in addition to acting as a ribonuclease, angiogenin may play a role in regulating gene expression by direct binding to DNA in the nucleus. Expand
Parcs Is a Dual Regulator of Cell Proliferation and Apaf-1 Function*
It is concluded that Parcs may define a molecular checkpoint in the control of cell proliferation for normal cells that is lost in tumor cells. Expand