• Publications
  • Influence
Human but Not Yeast CHD1 Binds Directly and Selectively to Histone H3 Methylated at Lysine 4 via Its Tandem Chromodomains*
Defining the protein factors that directly recognize post-translational, covalent histone modifications is essential toward understanding the impact of these chromatin “marks” on gene regulation. InExpand
  • 400
  • 28
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.
Trimethylation of histone H3 on lysine 4 (H3K4me3) localizes near the 5' region of genes and is tightly associated with active loci. Several proteins, such as CHD1, BPTF, JMJD2A, and the ING tumorExpand
  • 526
  • 22
Wss1 Is a SUMO-Dependent Isopeptidase That Interacts Genetically with the Slx5-Slx8 SUMO-Targeted Ubiquitin Ligase
ABSTRACT Protein sumoylation plays an important but poorly understood role in controlling genome integrity. In Saccharomyces cerevisiae, the Slx5-Slx8 SUMO-targeted Ub ligase appears to be needed toExpand
  • 51
  • 9
PIF1 family DNA helicases suppress R-loop mediated genome instability at tRNA genes
Saccharomyces cerevisiae encodes two Pif1 family DNA helicases, Pif1 and Rrm3. Rrm3 promotes DNA replication past stable protein complexes at tRNA genes (tDNAs). We identify a new role for the Pif1Expand
  • 54
  • 5
Binding and Activation of DNA Topoisomerase III by the Rmi1 Subunit*
Rmi1 is a conserved oligonucleotide and oligosaccharide binding-fold protein that is associated with RecQ DNA helicase complexes from humans (BLM-TOP3α) and yeast (Sgs1-Top3). Although human RMI1Expand
  • 63
  • 4
An essential DNA strand‐exchange activity is conserved in the divergent N‐termini of BLM orthologs
The gene mutated in Bloom's syndrome, BLM, encodes a member of the RecQ family of DNA helicases that is needed to suppress genome instability and cancer predisposition. BLM is highly conserved andExpand
  • 26
  • 2
  • Open Access
Molecular cloning and functional identification of invertase isozymes from green bamboo Bambusa oldhamii.
Three Bo beta fruct cDNAs encoding acid invertases were cloned from shoots of the green bamboo Bambusa oldhamii. On the basis of the amino acid sequences of their products and phylogenetic analyses,Expand
  • 28
  • 2
Two Pif1 Family DNA Helicases Cooperate in Centromere Replication and Segregation in Saccharomyces cerevisiae
Pif1 family helicases are found in virtually all eukaryotes. Saccharomyces cerevisiae (Sc) encodes two Pif1 family helicases, ScPif1 and Rrm3. ScPif1 is multifunctional, required not only forExpand
  • 9
  • 1
Assessing carbon footprint in the life cycle of accommodation services: the case of an international tourist hotel
The accommodation sector is the most demanding energy consumer among all building stock categories. This study quantifies an international tourist hotel in Taiwan to holistically estimate theExpand
  • 7
  • 1
Saccharomyces cerevisiae Centromere RNA Is Negatively Regulated by Cbf1 and Its Unscheduled Synthesis Impacts CenH3 Binding
Two common features of centromeres are their transcription into noncoding centromere RNAs (cen-RNAs) and their assembly into nucleosomes that contain a centromere-specific histone H3 (cenH3). Here,Expand
  • 3