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We performed a genome-wide association study (GWAS) of systemic lupus erythematosus (SLE) in a Chinese Han population by genotyping 1,047 cases and 1,205 controls using Illumina Human610-Quad BeadChips and replicating 78 SNPs in two additional cohorts (3,152 cases and 7,050 controls). We identified nine new susceptibility loci (ETS1, IKZF1, RASGRP3,(More)
Jasmonates play a number of diverse roles in plant defense and development. CORONATINE INSENSITIVE1 (COI1), an F-box protein essential for all the jasmonate responses, interacts with multiple proteins to form the SCF(COI1) E3 ubiquitin ligase complex and recruits jasmonate ZIM-domain (JAZ) proteins for degradation by the 26S proteasome. To determine which(More)
Most biological processes are mediated by interactions between proteins and their interacting partners including proteins, nucleic acids and small molecules. This work establishes a method called PINUP for binding site prediction of monomeric proteins. With only two weight parameters to optimize, PINUP produces not only 42.2% coverage of actual interfaces(More)
Detecting network path anomalies generally requires examining large volumes of traffic data to find misbehavior. We observe that wide-area services, such as peerto-peer systems and content distribution networks, exhibit large traffic volumes, spread over large numbers of geographically-dispersed endpoints. This makes them ideal candidates for observing(More)
BACKGROUND The narrow host range of Mycobacterium leprae and the fact that it is refractory to growth in culture has limited research on and the biologic understanding of leprosy. Host genetic factors are thought to influence susceptibility to infection as well as disease progression. METHODS We performed a two-stage genomewide association study by(More)
In data mining applications and spatial and multimedia databases, a useful tool is the <i>k</i>NN join, which is to produce the <i>k</i> nearest neighbors (NN), from a dataset <i>S</i>, of every point in a dataset <i>R</i>. Since it involves both the join and the NN search, performing <i>k</i>NN joins efficiently is a challenging task. Meanwhile,(More)
Structure prediction on a genomic scale requires a simplified energy function that can efficiently sample the conformational space of polypeptide chains. A good energy function at minimum should discriminate native structures against decoys. Here, we show that a recently developed, residue-specific, all-atom knowledge-based potential (167 atomic types)(More)
Accurate prediction of antigenic epitopes is important for immunologic research and medical applications, but it is still an open problem in bioinformatics. The case for discontinuous epitopes is even worse - currently there are only a few discontinuous epitope prediction servers available, though discontinuous peptides constitute the majority of all B-cell(More)
We present a novel global stereo model designed for view interpolation. Unlike existing stereo models which only output a disparity map, our model is able to output a 3D triangular mesh, which can be directly used for view interpolation. To this aim, we partition the input stereo images into 2D triangles with shared vertices. Lifting the 2D triangulation to(More)