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Efficient chemotaxis requires directional sensing and cell polarization. We describe a signaling mechanism involving G beta gamma, PAK-associated guanine nucleotide exchange factor (PIX alpha), Cdc42, and p21-activated kinase (PAK) 1. This pathway is utilized by chemoattractants to regulate directional sensing and directional migration of myeloid cells. Our(More)
* move toward higher concentrations of chemoattractants. Summary Cdc42 has been shown to interact with and/or activate proteins known to be involved in cytoskeleton reorgani-Efficient chemotaxis requires directional sensing and zation, including the PAK kinases and Wiscott Aldrich cell polarization. We describe a signaling mechanism syndrome protein (WASP)(More)
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