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Broad neutralization coverage of HIV by multiple highly potent antibodies
TLDR
Analysis of neutralization by the full complement of anti-HIV broadly neutralizing monoclonal antibodies now available reveals that certain combinations of antibodies should offer markedly more favourable coverage of the enormous diversity of global circulating viruses than others and these combinations might be sought in active or passive immunization regimes. Expand
Printed covalent glycan array for ligand profiling of diverse glycan binding proteins.
TLDR
A glycan microarray constructed by using standard robotic microarray printing technology to couple amine functionalized glycans to an amino-reactive glass slide has remarkable utility for profiling the specificity of a diverse range of glycan binding proteins. Expand
A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield
TLDR
The data suggest that the high neutralization potency of PGT 127 and 128 immunoglobulin Gs may be mediated by cross-linking Env trimers on the viral surface. Expand
Recognition of bacterial glycosphingolipids by natural killer T cells
TLDR
It is shown that most mouse and human NKT cells recognize glycosphingolipids from Sphingomonas, Gram-negative bacteria that do not contain lipopolysaccharide, and that these cells might be useful in providing protection from bacteria that cannot be detected by pattern recognition receptors such as Toll-like receptor 4. Expand
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo
TLDR
Chemical modulation reveals differences in S1P-S1P1 'set points' among tissues and highlights both mechanistic advantages (lymphocyte sequestration) and risks (pulmonary edema) of therapeutic intervention. Expand
Sulfatases: structure, mechanism, biological activity, inhibition, and synthetic utility.
TLDR
Accounts of the diversity and growing biological relevance of sulfatases are provided along with an overview of the current understanding of sulf atase structure, mechanism, and inhibition. Expand
Small molecules targeting severe acute respiratory syndrome human coronavirus.
TLDR
A cell-based assay was developed to screen existing drugs, natural products, and synthetic compounds to identify effective anti-SARS agents, and of particular interest are the two anti-HIV agents, one as an entry blocker and the other as a 3CL protease inhibitor. Expand
Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria
TLDR
It is shown that mouse and human NKT cells also recognized glycolipids, specifically a diacylglycerol, from Borrelia burgdorferi, which causes Lyme disease, suggesting that NKT cell responses driven by T cell receptor–mediated glycolIPid recognition may provide protection against diverse pathogens. Expand
Identification of an IL-17–producing NK1.1neg iNKT cell population involved in airway neutrophilia
TLDR
This study identifies a particular set of iNKT cells that lack the NK1.1neg marker and represents a new population of IL-17–producing cells that can contribute to neutrophil recruitment through preferential IL- 17 secretion. Expand
Chemical chaperones increase the cellular activity of N370S β-glucosidase: A therapeutic strategy for Gaucher disease
TLDR
It is proposed that NN-DNJ chaperones β-Glu folding at neutral pH allows the stabilized enzyme to transit from the endoplasmic reticulum to the Golgi, enabling proper trafficking to the lysosome. Expand
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