Chetana Chandrashekar

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PURPOSE The clinical behavior of unicystic ameloblastoma varies according to its subtype. The assessment of its proliferative capacity, neovascularization, and invasiveness using relevant immunomarkers may aid in appropriate surgical therapeutic protocol. METHODS 18 cases of clinically and histologically confirmed unicystic ameloblastoma, categorized as(More)
Epithelial-mesenchymal transition (EMT), a key developmental program has been shown to occur in wound healing, organ fibrosis and in the initiation of metastasis for cancer progression. EMT is a process that describes the development of motile, mesenchymal-like cells from non-motile parent epithelial cells. Plasticity of the cells enable significant changes(More)
OBJECTIVE To assess the expression of β-catenin in benign and malignant salivary gland tumors and to investigate the possible role of β-catenin in the behavior of salivary gland tumors. STUDY DESIGN Paraffin embedded tissues from 45 salivary gland tumors were studied immunohistochemically for expression of β-catenin. RESULT Reduced/aberrant β-catenin(More)
Experiments were conducted on pre-selected highly productive sugarcane hybrid clones under organic and integrated cultivation practices across five locations in northern Karnataka, India during the season 2011–2012. Twenty productive clones with five commercial varieties were evaluated for cane yield, jaggery yield and quality parameters. The varieties(More)
OBJECTIVES To determine the oral candidal carriage (OCC), activity of virulent factors and fluconazole susceptibility in subjects with type 2 diabetes mellitus (T2DM) and investigate their association with HbA1c measurements. MATERIALS AND METHODS A cross sectional study was conducted on 100 diabetics and 100 healthy volunteers. The virulence was assessed(More)
Oral squamous cell carcinomas comprise a heterogeneous tumor cell population with varied molecular characteristics, which makes prognostication of these tumors a complex and challenging issue. Thus, molecular profiling of these tumors is advantageous for an accurate prognostication and treatment planning. This is a retrospective study on a cohort of primary(More)
About 20% of the world's population uses some form of betel nut, which suggests that the incidence of oral submucous fibrosis (OSF) is higher than current estimates. OSF has the potential to undergo malignant transformation; thus, there is a need to identify relevant markers to assess its aggressiveness. We evaluated changes in COX-2, p53, and MDM2(More)
Laser capture microdissection (LCM) is a high-end research and diagnostic technology that helps in obtaining pure cell populations for the purpose of cell- or lesion-specific genomic and proteomic analysis. Literature search on the application of LCM in oral tissues was made through PubMed. There is ample evidence to substantiate the utility of LCM in(More)
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