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- Chetan T. Goudar, Richard K Biener, +4 authors Konstantin Konstantinov
- Metabolic engineering
- 2010

The physiological state of CHO cells in perfusion culture was quantified by determining fluxes through the bioreaction network using (13)C glucose and 2D-NMR spectroscopy. CHO cells were cultivated… (More)

- Chetan T. Goudar, Steve K Harris, Michael J McInerney, Joseph M Suflita
- Journal of microbiological methods
- 2004

We present a simple method for estimating kinetic parameters from progress curve analysis of biologically catalyzed reactions that reduce to forms analogous to the Michaelis-Menten equation.… (More)

- Chetan T. Goudar, James M. Piret, Konstantinov B Konstantinov
- Biotechnology progress
- 2011

We present robust methods for online estimation of cell specific oxygen uptake and carbon dioxide production rates (q(O2) and q(CO2), respectively) during perfusion cultivation of mammalian cells.… (More)

- Chetan T. Goudar, Klaus Joeris, Konstantin B. Konstantinov, James M. Piret
- Biotechnology progress
- 2005

A four-parameter logistic equation was used to fit batch and fed-batch time profiles of viable cell density in order to estimate net growth rates from the inoculation through the cell death phase.… (More)

- Chetan T. Goudar, Ricaredo Matanguihan, +4 authors Konstantin B. Konstantinov
- Biotechnology and bioengineering
- 2007

High-density perfusion cultivation of mammalian cells can result in elevated bioreactor CO(2) partial pressure (pCO(2)), a condition that can negatively influence growth, metabolism, productivity,… (More)

- Chetan T. Goudar, J. R. Sonnad, R. G. Duggleby
- Biochimica et biophysica acta
- 1999

A novel method of estimating enzyme kinetic parameters is presented using the Lambert omega function coupled with nonlinear regression. Explicit expressions for the substrate and product… (More)

- Chetan T. Goudar, Konstantinov B Konstantinov, James M. Piret
- Biotechnology progress
- 2009

Methods for robust logistic modeling of batch and fed-batch mammalian cell cultures are presented in this study. Linearized forms of the logistic growth, logistic decline, and generalized logistic… (More)

- J. R. Sonnad, Chetan T. Goudar
- Mathematical biosciences and engineering : MBE
- 2009

We present a low-order recursive solution to the Michaelis-Menten equation using the decomposition method. This solution is algebraic in nature and provides a simpler alternative to numerical… (More)

- Chetan T. Goudar, J. F. Devlin
- Water environment research : a research…
- 2001

A computer program (BIOKINFIT) was developed to estimate microbial and enzyme kinetic parameters from progress curve data by nonlinear regression. BIOKINFIT overcomes the limitations associated with… (More)

- Chetan T. Goudar, Keith A. Strevett
- Journal of Industrial Microbiology and…
- 1998

Biodegradation of BTEX by a microbial consortium isolated from a closed municipal landfill was studied using respirometric techniques. The kinetics of biodegradation were estimated from experimental… (More)