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Paclitaxel formulations: challenges and novel delivery options.
Paclitaxel (PTX), a taxane plant product, is one of the most effective broad-spectrum anti-cancer agents and approved for the treatment of a variety of cancers including ovarian, breast, lung, headExpand
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Development and evaluation of paclitaxel loaded PLGA:poloxamer blend nanoparticles for cancer chemotherapy.
  • P. Gupta, S. Jain, +6 authors S. Singh
  • Materials Science, Medicine
  • International journal of biological…
  • 1 August 2014
This investigation described the development of novel PLGA:poloxamer blend nanoparticles for intravenous administration of paclitaxel in order to limit the cremophor-associated adverse effects. TheExpand
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Redox Responsive Polymersomes for Enhanced Doxorubicin Delivery.
In the present investigation, the potential of a novel, self-assembled, biocompatible, and redox-sensitive copolymer system with disulfide bond was explored for doxorubicin (DOX) delivery throughExpand
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Self assembled dual responsive micelles stabilized with protein for co-delivery of drug and siRNA in cancer therapy.
Design of safe and efficient vehicles for the combinatorial delivery of drugs and genetic agents is an emerging requisite for achieving enhanced therapeutic effect in cancer. Even though severalExpand
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Combinatorial delivery of superparamagnetic iron oxide nanoparticles (γFe2O3) and doxorubicin using folate conjugated redox sensitive multiblock polymeric nanocarriers for enhancing the
Redox sensitive, folate conjugated multiblock polymeric system of (-PLGA-PEG-PLGA-urethane-ss-) demonstrated self-assembly into stable nanoplatforms. The polymeric nanocarriers were encapsulated withExpand
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Recent Advances in Chitosan-Based Nanomedicines for Cancer Chemotherapy
Chitosan, a cationic polysaccharide, has prompted the continuous impetus for the development of tumor targeted drug delivery systems, thanks to the polymer’s biocompatibility, low toxicity, andExpand
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Water dispersible CoFe2O4 nanoparticles with improved colloidal stability for biomedical applications
Abstract Single phase cobalt ferrite (CoFe2O4, CFO) nanoparticles of a controlled size (∼6 nm) exhibiting superparamagnetic properties have been synthesized by hydrothermal technique using oleic acidExpand
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ATRP Fabricated and Short Chain Polyethylenimine Grafted Redox Sensitive Polymeric Nanoparticles for Codelivery of Anticancer Drug and siRNA in Cancer Therapy.
To overcome the limitations of conventional chemotherapy, nanoparticle-mediated combinatorial delivery of siRNA and drugs represents a new approach to overcome its associated side effects. DesigningExpand
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Design, preparation, and evaluation of liposomal gel formulations for treatment of acne: in vitro and in vivo studies
Abstract The study highlights the significance of co-application of bioactive components into liposomal gel formulations and their comparison to azithromycin for treatment of Acne. A Design ofExpand
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Click modified amphiphilic graft copolymeric micelles of poly(styrene-alt-maleic anhydride) for combinatorial delivery of doxorubicin and plk-1 siRNA in cancer therapy.
The anti-apoptotic defense mechanism of cancer cells poses a major hurdle which makes chemotherapy less effective. Combinatorial delivery of drugs and siRNAs targeting anti-apoptotic proteins is aExpand
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