Cheryl Jorcyk

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Tumor cell lines that can be tracked in vivo during tumorigenesis and metastasis provide vital tools for studying the specific cellular mechanisms that mediate these processes as well as investigating therapeutic targets to inhibit them. The goal of this study was to engineer imageable mouse mammary tumor cell lines with discrete propensities to metastasize(More)
Metastatic events to the bone occur frequently in numerous cancer types such as breast, prostate, lung, and renal carcinomas, melanoma, neuroblastoma, and multiple myeloma. Accumulating evidence suggests that the inflammatory cytokine interleukin (IL)-6 is frequently upregulated and is implicated in the ability of cancer cells to metastasize to bone. IL-6(More)
Alterations in apoptosis and associated mechanisms during mammary tumor progression were investigated in transgenic mice expressing the SV40 large T antigen (TAG) driven by the rat prostatic steroid-binding protein C3(l) 5'-flanking region. Apoptosis levels, assessed by in situ end labeling, were low in normal mammary epithelial cells, highest in atypical(More)
Bone deterioration is a challenge in long-term spaceflight with significant connections to patients experiencing disuse bone loss. Prolonged unloading and radiation exposure, defining characteristics of space travel, have both been associated with changes in inflammatory signaling via IL-6 class cytokines in bone. While there is also evidence for perturbed(More)
The following individuals read and discussed the thesis submitted by student Stephanie Wyler, and they evaluated her presentation and response to questions during the final oral examination. They found that the student passed the final oral examination. DEDICATION This thesis is dedicated my family and colleagues. First and foremost to my brother, James(More)
CoVE is a novel, scalable, interactive tool that can be used to visualize and manage large colonies of laboratory animals. Effective management of large colonies of animals with multiple individual attributes and complicated breeding schemes represents a significant data management challenge in the biological sciences. Currently available software either(More)
Stüve-Wiedemann syndrome (STWS; OMIM #610559) is a rare bent-bone dysplasia that includes radiologic bone anomalies, respiratory distress, feeding difficulties, and hyperthermic episodes. STWS usually results in infant mortality, yet some STWS patients survive into and, in some cases, beyond adolescence. STWS is caused by a mutation in the leukemia(More)
The potential for inferring the presence of cancer by the detection of miRNA in human blood has motivated research into the design and operation of DNA-based chemical amplifiers that can operate in bodily fluids. As a first step toward this goal, we have tested the operation of a DNA-based autocatalytic network in human serum and mouse serum. With the(More)
The following individuals read and discussed the thesis submitted by student Nathan James Hoskins, and they evaluated his presentation and response to questions during the final oral examination. They found that the student passed the final oral examination. iii ACKNOWLEDGEMENTS I would like to thank everyone who made this thesis possible. First of all, I(More)