Cheryl J. Flynn

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This paper reports two cases of acrometastasis to the hands. The first case involved a 78-year-old woman with a permeative osteolytic lesion in her proximal second metacarpal. A biopsy of this lesion suggested a diagnosis of non-small-cell lung carcinoma with secondary osseous metastasis. This was the first presentation of the woman's primary diagnosis. A(More)
The main objective of this study was to determine whether the excitotoxic cholinesterase inhibitor soman increases the catabolism of phospholipids in rat brain. Injections of soman (70 micrograms/kg, s.c.), at a dose that produced toxic effects, increased the levels of both free fatty acids (175-250% of control) and free choline (250% of control) in rat(More)
The role of cholinergic and non-cholinergic mechanisms in mediating organophosphate cholinesterase (ChE) inhibitor-induced elevations in choline levels in brain was investigated. The nerve agents soman and sarin, when administered to rats at doses greater than the IC50 for acetylChE inhibition, significantly increased the levels of choline and acetylcholine(More)
RATIONALE Prior studies had suggested (a) that a lessened ability to clear ingested forms of the large neutral amino acid (LNAA), phenylalanine (Phe), was associated with having tardive dyskinesia (TD), and (b) that greater availability of a group of LNAA, the branched chain amino acids (BCAA), concomitant with the lower availability of Phe to the brain are(More)
In this report, we describe the fractionation of crude axolemmal fractions from rat lower brainstem into subfractions enriched in markers for either periaxolemmal myelin or axolemma. These subfractions were isolated on density gradients as bands layering on 0.8M and 1.0M sucrose. Both subfractions consisted of unilamellar vesicles. Relative to myelin(More)
PURPOSE Reports investigating whether the response rates to palliative radiation therapy (RT) for painful bone metastases from gastrointestinal (GI) cancers are similar to rates for bone metastases from other primary cancer sites have been limited. The present study evaluated response rates for symptomatic bone metastases from gi cancers after palliative(More)
Private record linkage is the problem of identifying pairs of records that are similar as per an input matching rule from databases that are held by two parties that do not trust one another. We identify three key desiderata that a PRL solution must ensure: a proof of end-to-end privacy, communication and computational costs that scale subquadrat-ically in(More)
Measurement of the lexical properties of domain names enables many types of relatively fast, lightweight web mining analyses. These include unsupervised learning tasks such as automatic categorization and clustering of websites, as well as supervised learning tasks, such as classifying websites as malicious or benign. In this paper we explore whether these(More)
Acute leukaemias are relatively common malignancies. Treatment has advanced significantly in the recent past and there has been improved patient survival. This improved initial response is leading to an increasing number of cases of relapse. Extramedullary relapse occurs in a wide variety of locations with varying presentations, imaging findings and(More)
INTRODUCTION At first blush, many will question the need to put effort into the development of a practice guideline for uncomplicated pregnancies when such care seems so rudimentary and simplistic. However, the following points exemplify why a practice guideline for care of pregnant women with uncomplicated pregnancies is a worthy endeavor. 1. Antenatal(More)