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Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP
PTEN-induced putative kinase 1 (Pink1) is a recently identified gene linked to a recessive form of familial Parkinson's disease (PD). The kinase contains a mitochondrial localization sequence and isExpand
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Autocatalytic cleavage of myelin basic protein: an alternative to molecular mimicry.
Although multiple sclerosis (MS) is thought to be an autoimmune disease, the mechanisms by which immunodominant epitopes are generated and lymphocytes are activated are not known. Here, myelin basicExpand
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Cell‐extrinsic CTLA4‐mediated regulation of dendritic cell maturation depends on STAT3
Regulatory T (Treg) cells suppress immune responses by downregulating the expression of costimulatory molecules CD80 and CD86 on dendritic cells (DCs) through cytotoxic T lymphocyte antigen 4Expand
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Cholecalciferol plus calcium suppresses abnormal PBMC reactivity in patients with multiple sclerosis.
CONTEXT The active metabolite of vitamin D, 1,25-dihydroxyvitamin D [1,25(OH)(2)D], is a potent modulator of immune cells in vitro. OBJECTIVE Our objective was to determine whether theExpand
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Differences in Susceptibility of MBP Charge Isomers to Digestion by Stromelysin-1 (MMP-3) and Release of an Immunodominant Epitope
Charge microheterogeneity of myelin basic protein is known to affect its conformation and function. Here, the citrullinated myelin basic protein charge isomer, component-8, was shown to be moreExpand
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Cytosolic Proteins Regulate α-Synuclein Dissociation from Presynaptic Membranes*
Intracellular accumulation of insoluble α-synuclein in Lewy bodies is a key neuropathological trait of Parkinson disease (PD). Neither the normal function of α-synuclein nor the biochemicalExpand
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Allogeneic Human Double Negative T Cells as a Novel Immunotherapy for Acute Myeloid Leukemia and Its Underlying Mechanisms
Purpose: To explore the potential of ex vivo expanded healthy donor–derived allogeneic CD4 and CD8 double-negative cells (DNT) as a novel cellular immunotherapy for leukemia patients. ExperimentalExpand
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Trogocytosis of CD80 and CD86 by induced regulatory T cells
Trogocytosis is a process which involves the transfer of membrane fragments and cell surface proteins between cells. Various types of T cells have been shown to be able to acquire membrane-boundExpand
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Developing Allogeneic Double-Negative T Cells as a Novel Off-the-Shelf Adoptive Cellular Therapy for Cancer
Purpose: To expand clinical-grade healthy donor-derived double-negative T cells (DNT) to a therapeutically relevant number and characterize their potential to be used as an “off-the-shelf” adoptiveExpand
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Blocking GluR2–GAPDH ameliorates experimental autoimmune encephalomyelitis
Multiple sclerosis (MS) is the most common disabling neurological disease of young adults. The pathophysiological mechanism of MS remains largely unknown and no cure is available. Current clinicalExpand
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