Cherupally Dayakar

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1H-1,2,3-Triazolylbenzohydrazides (6a-h and 11a-l) were synthesized from 2-chloronicotinaldehydes and evaluated for anti-mycobacterial activity against Mycobacterium tuberculosis H37Rv strain (ATCC-27294). Seven compounds 6b, 6e,f, 11d, 11h, 11j and 11l displayed potent anti-mycobacterial activity (MIC 2.8-6.2 μM). Potent anti-mycobacterial compounds were(More)
A series of novel pyrazolyl alcohols (5a-h), pyrazolyl azides (6a-h), and pyrazolyltriazoles (8a-h, 10a-p and 12a-l) were prepared and evaluated for their bioactivity (anti-bacterial and anti-inflammatory) profile. The compound 5c displayed the potent anti-bacterial activity against Micrococcus luteus (MIC 3.9 and MBC 7.81µg/mL). In vitro anti-inflammatory(More)
A series of pyridinylchalcones 3a–q, chromanones 4a–q were prepared and screened for their in vitro anti-proliferative activity against four human cancer cell lines viz., cervical (HeLa), lung adenocarcinoma (A549), prostate (DU-145) and breast (MDA-MB-231). Pyridinylchalcones 3a-q and chromanones 4a-q exhibited IC50 values in the range of 5.9–289 µM.(More)
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