Chenxiang Tang

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The sterile alpha motif and HD domain-containing protein 1 (SAMHD1), a dNTPase, prevents the infection of nondividing cells by retroviruses, including HIV, by depleting the cellular dNTP pool available for viral reverse transcription. SAMHD1 is a major regulator of cellular dNTP levels in mammalian cells. Mutations in SAMHD1 are associated with chronic(More)
SAMHD1 is a cellular protein that plays key roles in HIV-1 restriction and regulation of cellular dNTP levels. Mutations in SAMHD1 are also implicated in the pathogenesis of chronic lymphocytic leukemia and Aicardi-Goutières syndrome. The anti-HIV-1 activity of SAMHD1 is negatively modulated by phosphorylation at residue Thr-592. The mechanism underlying(More)
SAMHD1-mediated HIV-1 restriction, and argues against a nucleolytic mechanism. Our data and two recent studies18,19 do not support the conclusion that the RNase activity of SAMHD1 is involved in its anti-HIV-1 activity7, but are in agreement with its dNTPase activity as mediating HIV-1 restriction. The discrepancy between our results and those of Ryoo et(More)
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