Chenxi He

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Classical animal visual deprivation studies and human neuroimaging studies have shown that visual experience plays a critical role in shaping the functionality and connectivity of the visual cortex. Interestingly, recent studies have additionally reported circumscribed regions in the visual cortex in which functional selectivity was remarkably similar in(More)
Previous studies have provided evidence for a tool-selective region in left lateral occipitotemporal cortex (LOTC). This region responds selectively to pictures of tools and to characteristic visual tool motion. The present human fMRI study tested whether visual experience is required for the development of tool-selective responses in left LOTC. Words(More)
The principles that determine the organization of object representations in ventral temporal cortex (VTC) remain elusive. Here, we focus on the parahippocampal place area (PPA), a region in medial VTC that has been shown to respond selectively to pictures of scenes. Recent studies further observed that this region also shows a preference for large(More)
Knowledge of object shape is primarily acquired through the visual modality but can also be acquired through other sensory modalities. In the present study, we investigated the representation of object shape in humans without visual experience. Congenitally blind and sighted participants rated the shape similarity of pairs of 33 familiar objects, referred(More)
In congenitally blind individuals, many regions of the brain that are typically heavily involved in visual processing are recruited for a variety of nonvisual sensory and cognitive tasks (Rauschecker 1995; Pascual-Leone et al. 2005). This phenomenon-cross-modal plasticity-has been widely documented, but the principles that determine where and how(More)
Regulation of enhancer activity is important for controlling gene expression programs. Here, we report that a biochemical complex containing a potential chromatin reader, RACK7, and the histone lysine 4 tri-methyl (H3K4me3)-specific demethylase KDM5C occupies many active enhancers, including almost all super-enhancers. Loss of RACK7 or KDM5C results in(More)
The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. Abstract ■ Previous studies have provided evidence for a tool-selective region in left lateral occipitotemporal cortex (LOTC). This region responds selectively to pictures of tools and to characteristic visual tool motion. The present(More)
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