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Genomic characterization of the conditionally dispensable chromosome in Alternaria arborescens provides evidence for horizontal gene transfer
TLDR
Evidence supporting the hypothesis that the CDC in A. arborescens was acquired through horizontal transfer, likely from an unrelated fungus is provided and several predicted CDC genes under positive selection that may serve as candidate virulence factors are identified. Expand
Genome comparison of two Magnaporthe oryzae field isolates reveals genome variations and potential virulence effectors
TLDR
This work used a next generation sequencing approach to analyze the genomes of two field isolates FJ81278 and HN19311 and identified extensive polymorphisms including unique genes, SNPs and indels, structural variations, copy number variations, and loci under strong positive selection. Expand
Histoplasma yeast and mycelial transcriptomes reveal pathogenic-phase and lineage-specific gene expression profiles
TLDR
Comparison of the yeast and mycelial transcriptomes highlights genes encoding virulence factors as well as those involved in protein glycosylation, alternative metabolism, lipid remodeling, and cell wall glycanases that may contribute to Histoplasma pathogenesis. Expand
ChIP‐seq reveals a role for CrzA in the Aspergillus fumigatus high‐osmolarity glycerol response (HOG) signalling pathway
TLDR
There is a genetic interaction between the A. fumigatus calcineurin‐CrzA and HOG pathway that is essential for full virulence, and several members of the two‐component system (TCS) and the HOG pathways were more sensitive to calcium. Expand
Sequence Variation and Recognition Specificity of the Avirulence Gene AvrPiz-T in Magnaporthe Oryzae Field Populations
TLDR
The diversity in coding sequence and the insertions of transposable elements in the promoter region enable M. oryzae to evade recognition by the cognate Piz-t R gene in the host. Expand
A distribution pattern assisted method of transcription factor binding site discovery for both yeast and filamentous fungi
TLDR
A new attribute-motif distribution pattern (MDP) is introduced to assist in transcription factor binding sites prediction and demonstrates superior prediction reranking results using MDP over the commonly used program MEME and the other four predictors. Expand
Protein research methods and applications in disease research
TLDR
The technologies that have been commonly used for nature analysis of protein, their application in a variety of diseases, and some current existing problems of those technologies, will be overviewed briefly. Expand