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Fragile histidine triad (FHIT) is a tumor suppressor protein that regulates cancer cell proliferation and apoptosis. However, its exact mechanism of action is poorly understood. Phosphatidylinositol 3-OH kinase (PI3K)-Akt-survivin is an important signaling pathway that was regulated by FHIT in lung cancer cells. To determine whether FHIT can regulate this(More)
BACKGROUND/AIMS The fragile histidine triad (FHIT) gene is a candidate tumor suppressor gene. Recent studies have found that FHIT protein is lost in digestive system neoplasms. However, there is limited information on the effect of FHIT on apoptosis and the regulation functions on cyclin D1 in cholangiocarcinoma. METHODOLOGY Eukaryotic expression plasmids(More)
BACKGROUND/AIMS To investigate the risk factors of postoperative complications of pancreaticoduodenectomy. METHODOLOGY 207 cases suffered from pancreatic carcinoma or periampullary carcinoma received pancreatoduodenectomy in the Anhui Provincial Hospital from Dec. 2007 to Dec. 2012 were analyzed. 17 clinicopathologic factors that could possibly influence(More)
OBJECTIVE To evaluate the clinical value of a preoperative predictive scoring system which was established by the National Cancer Center Hospital (NCCH) for the postoperative pancreatic fistula (POPF) after pancreaticoduodenectomy. METHODS The clinical data of 269 patients who underwent pancreaticoduodenectomy at the Affiliated Provincial Hospital of(More)
Bile duct injury (BDI) is one of the most severe complications of biliary operation. This study is to investigate the correlation between the timing of bile duct repair and anastomotic bile duct stricture. Transverse BDI models were constructed in 60 dogs that were divided randomly into BDI₅, BDI₁₀, BDI₁₅, BDI₂₀, and BDI₃₀ groups according to days of injury(More)
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