Chengzhang Li

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BACKGROUND AND OBJECTIVE CypA is able to regulate inflammatory responses and MMPs production via interaction with its cell surface receptor, EMMPRIN. This study aimed to address the possible association of CypA with pathological inflammation and destruction of periodontal tissues, and whether CypA-EMMPRIN interaction exists in periodontitis. MATERIALS AND(More)
BACKGROUND A single nucleotide polymorphism in the promoter region of -1607 bp of the human matrix metalloproteinase-1 (MMP-1) gene has been found to be associated with an increased risk of various inflammatory diseases and cancer metastasis. OBJECTIVES The present study aimed to examine the distribution of MMP-1 genotypes in a group of Chinese subjects(More)
OBJECTIVE To evaluate the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in healthy and inflamed human gingiva. METHOD AND MATERIALS Tissue samples from 9 healthy specimens and 21 specimens with chronic periodontitis were collected. The expression of EMMPRIN protein was detected with immunohistochemical staining and Western blot(More)
Alterations in the degree of the phosphorylation of ERK1/2, Akt-1 and p70 S6K in mouse skeletal and cardiac muscle was examined in vivo following an intraperitoneal injection of des IGF-I. Plasma levels of insulin, IGF-I and glucose were measured. The administration of des IGF-I had no effect on plasma levels of insulin, or IGF-I, but plasma glucose levels(More)
OBJECTIVES Polymorphisms for toll-like receptor (TLR) 2 gene (Arg677Trp, Arg753Gln) and TLR4 gene (Asp299Gly, Thr399Ile) that are associated with impaired lipopolysaccharide (LPS) signal transduction have recently been described. The present study aimed to investigate the relationship between TLRs 2 and 4 gene polymorphisms and periodontitis in a Chinese(More)
Periodontitis are characterized by the destruction of the extracellular matrix (ECM) of periodontal tissues. Matrix metalloproteinases (MMPs) play an important role in the degradation of ECM. But until now, it is not clear about the regulation of MMPs expression level in periodontitis. EMMPRIN is a 58 kDa, highly glycosylated, transmembrane molecule(More)
Supporting and enhancing the regeneration and stability of alveolar bone at dental implant sites is necessary to improve implant integration and stability. In this study chitosan/collagen scaffolds combined with adenoviruses expressing either bone morphogenetic protein 7 (BMP-7), platelet-derived growth factor B (PDGF-B), or a combination of both BMP-7 and(More)
Parathyroid hormone (PTH) functions as a major mediator of bone remodeling and as an essential regulator of calcium homeostasis. In addition to the well-established catabolic effects (activation of bone resorption) of PTH, it is now recognized that intermittent PTH administration has anabolic effects (promotion of bone formation). As one of the commonest(More)
Our previous research has proved that baicalin can inhibit the expression of Matrix metalloproteinases (MMPs) in periodontal ligament cells (PDLC) by cell immunocytochemistry. Therefore, the purpose of this study was to address the effects of baicalin on the total protein amount and Collagen I mRNA expression in PDLC, and the regulatory effects on Matrix(More)
This study aimed to establish a model of synaptic plasticity by the activation of metabotropic glutamate receptor (mGluR) I in rat medial septal diagonal band (MSDB). Electrophysiological experiment was performed to record the theta frequency oscillation activities in rat MSDB slices. The data were recorded and analyzed with Spike 2 (CED, Cambridge, UK).(More)