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Embryonic stem cell (ESC) pluripotency requires bivalent epigenetic modifications of key developmental genes regulated by various transcription factors and chromatin-modifying enzymes. How these factors coordinate with one another to maintain the bivalent chromatin state so that ESCs can undergo rapid self-renewal while retaining pluripotency is poorly(More)
Mitochondrial calcium has been postulated to regulate a wide range of processes from bioenergetics to cell death. Here, we characterize a mouse model that lacks expression of the recently discovered mitochondrial calcium uniporter (MCU). Mitochondria derived from MCU(-/-) mice have no apparent capacity to rapidly uptake calcium. Whereas basal metabolism(More)
This paper proposed a new entropy measure, Fuzzy Measure Entropy (FuzzyMEn), for the analysis of heart rate variability (HRV) signals. FuzzyMEn was calculated based on the fuzzy set theory and improved the poor statistical stability in the approximate entropy (ApEn) and sample entropy (SampEn). The simulation results also demonstrated that the FuzzyMEn had(More)
Growth hormone (GH) exerts diverse tissue-specific metabolic effects that are not revealed by global alteration of GH action. To study the direct metabolic effects of GH in the muscle, we specifically inactivated the growth hormone receptor (ghr) gene in postnatal mouse skeletal muscle using the Cre/loxP system (mGHRKO model). The metabolic state of the(More)
Signaling through the thrombospondin-1 receptor CD47 broadly limits cell and tissue survival of stress, but the molecular mechanisms are incompletely understood. We now show that loss of CD47 permits sustained proliferation of primary murine endothelial cells, increases asymmetric division, and enables these cells to spontaneously reprogram to form(More)
Complexity of heartbeat interval series is typically measured by entropy. Recent studies have found that sample entropy (SampEn) or fuzzy entropy (FuzzyEn) quantifies essentially the randomness, which may not be uniformly identical to complexity. Additionally, these entropy measures are heavily dependent on the predetermined parameters and confined to data(More)
Understanding insulin-like growth factor-1 (IGF1) biology is of particular importance because, apart from its role in mediating growth, it plays key roles in cellular transformation, organ regeneration, immune function, development of the musculoskeletal system and aging. IGF1 bioactivity is modulated by its binding to IGF-binding proteins (IGFBPs) and the(More)
Stem cell differentiation is accompanied by a gradual cellular morphogenesis and transcriptional changes. Identification of morphological regulators that control cell behavior during differentiation could shed light on how cell morphogenesis is coupled to transcriptional changes during development. By analyzing cellular behavior during differentiation of(More)
SELinux can enforce a policy based on mandatory access control (MAC) for Linux so as to fulfill the security requirements of more strict access control for those hierarchical and classified management organizations or situations. But security policy configuration is a hard and intractable task for SELinux due to its recondite policy description language and(More)