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The three tandem-arrayed protocadherin (Pcdh) gene clusters, namely Pcdh-alpha, Pcdh-beta, and Pcdh-gamma, play important roles in the development of the vertebrate central nervous system. To gain insight into the molecular action of PCDHs, we performed a systematic proteomics analysis of PCDH-gamma-associated protein complexes. We identified a list of 154(More)
Genetic studies demonstrate that gamma-protocadherins (PCDH-gamma) are required for the survival and synaptic connectivity in neuronal subpopulations of the central nervous system. However, the intracellular signaling mechanisms for PCDH-gamma are poorly understood. Here, we show that PCDH-gamma binds two tyrosine kinases, PYK2 and focal adhesion kinase(More)
The chicken spinal cord is an excellent model for the study of early neural development in vertebrates. However, the lack of robust, stable and versatile transgenic methods has limited the usefulness of chick embryos for the study of later neurodevelopmental events. Here we describe a new transgenic approach utilizing the PiggyBac (PB) transposon to(More)
Introduction: Based on its petrography and mineralogy , the Antarctic meteorite Grove Mountains (GRV) 99027 has been classified as the fourth known lherzolitic shergottite, after ALH 77005, Yamato 793605 and LEW 88516 [1, 2]. It consists mainly of olivine (Fa 24-31), low-(En 61-76 Fs 21-27 Wo 3-14) and high-(En 48-52 Fs 13-16 Wo 33-38) Ca pyroxenes, and(More)
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