Chengxiao Wang

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Crohn's disease (CD) is one of the two major types of inflammatory bowel disease (IBD) thought to be caused by genetic and environmental factors. Recently, miR-122 was found to be deregulated in association with CD progression. However, the underlying molecular mechanisms remain unclear. In the present study, the gene nucleotide-binding oligomerization(More)
OBJECTIVE To establish a stable culture system of mouse embryonic fibroblast(MEF). METHODS We isolated MEF from the embryos of BALB/c mouse and investigated the morphology, growth curve and cell cycle of MEF in vitro. The effects of the gestational age (days) of mouse embryos and the time of digestion on the isolation and culture of MEF were assessed. (More)
We prepared pressure-sensitive adhesive (PSA) patches based on styrene–isoprene–styrene (SIS) thermoplastic elastomer using hot-melt coating method. The liquid paraffine is added in the PSA matrices as a plasticizer to moderate the PSA properties. Three drugs, methyl salicylate, capsaicin, and diphenhydramine hydrochloride are selected as model drugs. The(More)
OBJECTIVE To design and evaluate a novel pressure sensitive adhesive (PSA) patch containing traditional Chinese medicine (TCM) using styrene-isoprene-styrene (SIS) copolymer. METHOD A mixture D-optimal design with ternary response surface diagram was employed in the optimization process. The proportions of SIS copolymer, tackifying resin and plasticizer(More)
The purpose of the present study was to design and evaluate a monolithic drug-in-adhesive patch with a novel pressure-sensitive adhesive (PSA) matrix based on styrene-isoprene-styrene (SIS) block copolymer. Testosterone was selected as the model drug. The orthogonal array design for ternary mixtures was employed to optimize the amounts of SIS, C-5(More)
Natural polysaccharides are highly valued and extensively applied in drug delivery system for their desirable physical properties and unique bioactivities. In this work, natural polysaccharides from Bletilla striata (BSP) were successfully extracted and incorporated with Carbopol 940 to prepare hydrogels. Rheological behavior, skin permeation properties and(More)
OBJECTIVE To investigate and evaluate a clinically perspective way of inducing transplantation tolerance. METHODS Multi-cord blood transfusion was performed before kidney transplantation in 20 cases. Donor-specific mixed lymphocyte reaction(MLR) and allograft rejection were observed and studied. RESULTS The donor-specific MLR was suppressed in every(More)
An isobaric tags for relative and absolute quantitative (iTRAQ)-based quantitative proteomic approach was used to screen the differentially expressed proteins during control treatment (CK), aluminum (Al) and Al+ indole-3-acetic acid (IAA) treatment of wheat lines ET8 (Al-tolerant). Further, the the expression levels of auxin response factor (ARF), Aux/IAA,(More)
To evaluate the feasibility of using human embryonic fibroblast(HEF) as feeder layer in the culture of human embryonic stem(ES) cells in vitro, we investigated the morphology, the sensitivity to 0.25% trypsin, the growth curve and cell cycle of HEF with DMEM(low glucose) +10% FBS used as culture medium, and then we compared HEF with mouse embryonic(More)
A novel drug-in-adhesive matrix was designed and prepared. A thermoplastic elastomer, styrene–isoprene–styrene (SIS) block copolymer, in combination with tackifying resin and plasticizer, was employed to compose the matrix. Capsaicin was selected as the model drug. The drug percutaneous absorption, adhesion properties, and skin irritation were investigated.(More)
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