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Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy
TLDR
Three-dimensional multiphoton vibrational imaging technique based on stimulated Raman scattering (SRS) is reported, which offers background-free and readily interpretable chemical contrast in biomedical imaging and shows a variety of biomedical applications. Expand
Improved spatial learning performance of fat-1 mice is associated with enhanced neurogenesis and neuritogenesis by docosahexaenoic acid
TLDR
Increased brain DHA significantly enhances hippocampal neurogenesis shown by an increased number of proliferating neurons and neuritogenesis, evidenced by increased density of dendritic spines of CA1 pyramidal neurons in the hippocampus, and this effect may be a mechanism underlying its beneficial effect on behavioral performance. Expand
Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways
TLDR
The results demonstrated that BBR induced a typical hormetic response in PC12 cells, and strongly suggested that the neuroprotection of BBR were attributable to the hormetic mechanisms via activating cell survival and antioxidant signaling pathways. Expand
Herbal medicines for the prevention of alcoholic liver disease: a review.
TLDR
All reported extracts and individual compounds from herbal medicines/natural plants could be beneficial to ALD, which might be attributed to regulate multiple critical targets involved in the pathways of oxidation, inflammation and lipid metabolism. Expand
Polyphyllin VII induces apoptosis in HepG2 cells through ROS-mediated mitochondrial dysfunction and MAPK pathways
TLDR
It is demonstrated that PP7 induced apoptotic cell death in HepG2 cells through both intrinsic and extrinsic pathways by promoting the generation of mitochondrial-mediated ROS and activating MAPK and PTEN/p53 pathways. Expand
Polyphyllin VII Induces an Autophagic Cell Death by Activation of the JNK Pathway and Inhibition of PI3K/AKT/mTOR Pathway in HepG2 Cells
TLDR
This is the first report that PP7 induces an autophagic cell death in HepG2 cells via inhibition of PI3K/AKT/mTOR, and activation of JNK pathway, which induces phosphorylation of Bcl-2 and dissociation of Beclin-1 from BeclIn-1/Bcl- 2 complex, leading to induction of autophagy. Expand
Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways
TLDR
Low dose PTS could significantly prevent the 6-OHDA-induced dopaminergic neuron loss and improve the behavior movement deficiency in zebrafish, whereas relative high dose PTS exhibited neural toxicity, further supporting the hormetic and neuroprotective effects of PTS. Expand
Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines.
  • Li-li Huang, J. Wan, +4 authors J. Kang
  • Chemistry, Medicine
  • Prostaglandins, leukotrienes, and essential fatty…
  • 1 May 2013
TLDR
It is demonstrated that DHA supplementation protects against acute ethanol-induced hepatic steatosis, which may be associated with reduced expression of SCD-1 and inflammatory cytokines. Expand
Panax notoginseng reduces atherosclerotic lesions in ApoE-deficient mice and inhibits TNF-alpha-induced endothelial adhesion molecule expression and monocyte adhesion.
  • J. Wan, S. Lee, +4 authors J. Kang
  • Chemistry, Medicine
  • Journal of agricultural and food chemistry
  • 12 August 2009
TLDR
In conclusion, PNS has antiatherogenic activity through, at least in part, its lipid-lowering and antivascular inflammatory mechanisms. Expand
Enriched endogenous omega-3 fatty acids in mice protect against global ischemia injury
TLDR
It is demonstrated that fat-1 mice with high endogenous ω-3 PUFAs exhibit protective effects on hippocampal CA1 neurons and cognitive functions in a global ischemia injury model. Expand
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