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The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
In this alternative model of tumorigenesis, the epithelial cancer cells instruct the normal stroma to transform into a wound-healing stroma, providing the necessary energy-rich micro-environment for facilitating tumor growth and angiogenesis, explaining its powerful predictive value.
Minireview: Cyclin D1: normal and abnormal functions.
- M. Fu, Chenguang Wang, Zhiping Li, T. Sakamaki, R. Pestell
- Biology, MedicineEndocrinology
- 1 December 2004
Accumulating evidence suggests that in addition to its original description as a CDK-dependent regulator of the cell cycle, cyclin D1 also conveys cell cycle orCDK-independent functions.
Autophagy in cancer associated fibroblasts promotes tumor cell survival
A loss of stromal fibroblast Cav-1 is a biomarker for chronic hypoxia, oxidative stress and autophagy in the tumor microenvironment, consistent with its ability to predict early tumor recurrence, lymph node metastasis and tamoxifen-resistance in human breast cancers.
Direct Acetylation of the Estrogen Receptor α Hinge Region by p300 Regulates Transactivation and Hormone Sensitivity*
It is shown that the estrogen receptor (ERα) is acetylated in vivo, and the conservation of the ERα acetylation motif in a phylogenetic subset of nuclear receptors suggests that direct acetylators may contribute to additional signaling pathways involved in metabolism and development.
Role of direct interaction in BRCA1 inhibition of estrogen receptor activity
It is found that breast cancer-associated mutations of BRCA1 abolish or reduce its ability to inhibit ER-α activity and that domains within the amino- and carboxyl-termini of the BRC a1 protein are required for the inhibition.
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution
Cancer cells use "oxidative stress" in adjacent fibroblasts as an "engine" to fuel their own survival via the stromal production of nutrients, and to drive their own mutagenic evolution towards a more aggressive phenotype, by promoting genomic instability.
Hormonal Control of Androgen Receptor Function through SIRT1
DHT-induced prostate cancer cellular contact-independent growth is also blocked by SIRT1, providing a direct functional link between the AR, which is a critical determinant of progression of human prostate cancer, and the sirtuins.
Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1.
CDK8 and CycC function as evolutionarily conserved components of the insulin signaling pathway in regulating lipid homeostasis and are identified as negative regulators of the lipogenic pathway in Drosophila, mammalian hepatocytes, and mouse liver.
Acetylation of Androgen Receptor Enhances Coactivator Binding and Promotes Prostate Cancer Cell Growth
ABSTRACT Modification by acetylation occurs at ε-amino lysine residues of histones and transcription factors. Unlike phosphorylation, a direct link between transcription factor acetylation and…
Cyclin D1 Regulates Cellular Migration through the Inhibition of Thrombospondin 1 and ROCK Signaling
Mutational analysis of cyclin D1 demonstrated that its effects on cellular adhesion and migration were independent of the pRb and p160 coactivator binding domains and promoted cellular motility through inhibiting ROCK signaling and repressing the metastasis suppressor TSP-1.