Chengtian Ye

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PURPOSE To establish a rabbit dry eye model with topical medication of the ocular preparation preservative benzalkonium chloride (BAC). METHODS Sixteen white rabbits were used. One eye of each rabbit was chosen randomly for topical administration of 0.1% BAC twice daily for 14 days. The other untreated eyes served as controls. Schirmer test, fluorescein,(More)
PURPOSE Pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone) is a new, broad-spectrum agent that has an inhibition effect on the proliferation, migration, and collagen contraction of human Tenon's fibroblasts, and thus modulating the wound healing process of glaucoma filtering surgical site. This study investigated the pharmacokinetics of topically administered(More)
OBJECTIVE To observe the effect of FK506 eye-drop combined with keratoplasty on recurrent Mooren's ulcer. METHODS 9 cases (15 eyes) of recurrent Mooren's ulcer were treated with topical FK506 eye-drop combined with keratoplasty. Of the 15 eyes, two of Mooren's ulcer smaller than half circle of the limbus were treated with 0.1% FK506 eye-drop. Among the(More)
OBJECTIVE To observe the effect of the Yiqimingmu solutions on electroretinogram of rats with retinal photochemical damage. METHODS Twenty-four SD rats were divided into four groups randomly: control group, model group, low dose group, high dose group. All groups except the control one were continually exposed to green fluoresent light with an level of(More)
CONTEXT Pirfinedone (PFD) is a novel agent which has the potential to prevent scarring in the eyes. The 0.5% PFD eye drops exhibits poor bioavailability. Whereas, the feasibility of using contact lens as ocular drug delivery device initiated novel possibilities. OBJECTIVE To evaluate the delivery of PFD by soft contact lens (SCL) in vivo, we screened the(More)
PURPOSE To investigate the experimental therapeutic effects of Chinese medicine Yiqimingmu solution on rats of retina injury models induced by light. METHODS Fifty-four Sprague-Dawley rats were randomly divided into negative control group, light damage model group and Yiqimingmu solution group. The light damage model was induced by exposing the SD rats'(More)
PURPOSE To evaluate the clinical efficacy of FK-506 on suppressing high-risk cornea transplantation rejection. METHODS In a randomized controlled clinical trial, 56 eyes of 56 patients with high-risk keratoplasty (including total corneal transplantation TCT, total corneal transplantation with circular lamellar sclera CST, vascularization corneal(More)
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