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  • Youshan Zhao, Dong Wu, +8 authors Chun-kang Chang
  • Biology, Medicine
  • Haematologica
  • 2015 (First Publication: 1 February 2015)
  • Although it has been reported that mesenchymal stromal cells are unable to provide sufficient hematopoietic support in myelodysplastic syndrome, the underlying mechanisms remain elusive. In thisContinue Reading
  • Chengming Fei, Youshan Zhao, +4 authors Chun-kang Chang
  • Medicine, Biology
  • Tumor Biology
  • 2013 (First Publication: 15 November 2013)
  • The pathogenesis of myelodysplastic syndromes (MDS) has not been completely understood, and insufficiency of the hematopoietic microenvironment can be an important factor. Mesenchymal stem cellsContinue Reading
  • Qingqing Zheng, Youshan Zhao, +7 authors Chun-kang Chang
  • Medicine, Biology
  • Cell Death & Disease
  • 2018 (First Publication: 1 May 2018)
  • Iron overload (IO) has been reported to contribute to mesenchymal stromal cell (MSC) damage, but the precise mechanism has yet to be clearly elucidated. In this study, we found that IO increased cellContinue Reading
  • Sida Zhao, Juan Guo, +4 authors Chun-kang Chang
  • Biology, Medicine
  • American journal of translational research
  • 2016 (First Publication: 15 July 2016)
  • Many studies have indicated that histone deacetylase (HDAC) activity is always increased in a lot of human tumors, and inhibition of HDAC activity is a promising new strategy in the treatment ofContinue Reading
  • Chengming Fei, Juan Guo, +4 authors Chun-kang Chang
  • Medicine
  • American journal of translational research
  • 2015 (First Publication: 15 October 2015)
  • Previous studies have demonstrated that bone marrow mesenchymal stromal cells (BMMSCs) from patients with myelodysplastic syndromes (MDS) display defective proliferative potential and impairedContinue Reading
  • Chengming Fei, Youshan Zhao, Juan Guo, Shucheng Gu, Xiao Li, Chun-kang Chang
  • Medicine
  • European journal of haematology
  • 2014 (First Publication: 1 December 2014)
  • The contribution of bone marrow mesenchymal stromal cells (BMMSCs) to the pathogenesis of myelodysplastic syndrome (MDS) has created controversies. In this study, we confirmed that BMMSCs from MDSContinue Reading
  • Juan Guo, Chengming Fei, +6 authors Chun-kang Chang
  • Medicine
  • Oncotarget
  • 2017 (First Publication: 15 July 2017)
  • Multiple myeloma (MM) always presents osteolytic bone lesions, resulting from the abnormal osteoblastic and osteoclastic function in patients. MM patients exhibit the impairment of osteogenicContinue Reading